交趾黄檀心材化学成分的研究  

Chemical constituents from the heartwood of Dalbergia cochinchinensis

作　　者：郑启万 任佳慧 刘洋[1] 危先文 孟晓伟[1] 杨丽[1] 陈兰英[1] 刘荣华[1] ZHENG Qi-wan;REN Jia-hui;LIU Yang;WEI Xian-wen;MENG Xiao-wei;YANG Li;CHEN Lan-ying;LIU Rong-hua(Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学,江西南昌330004

出　　处：《中成药》2023年第12期3980-3986,共7页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金(82160732);国家重点研发计划课题(2018YFC1706102);江西省自然科学基金(20202BABL216072)。

摘　　要：目的研究交趾黄檀Dalbergia cochinchinensis Pierre ex Laness心材的化学成分。方法交趾黄檀心材70%乙醇提取物采用硅胶、Sephadex LH⁃20、半制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到23个化合物,分别鉴定为3⁃O⁃乙酰基白桦酯醛(1)、2,2′⁃oxybis(1,4⁃di⁃tert⁃butylbenzene)(2)、对羟基苯甲酸乙酯(3)、1⁃乙酰基⁃Β⁃咔啉(4)、7⁃羟基二氢黄酮(5)、棕榈酸(6)、hexadeca⁃4,7⁃diene(7)、亚油酸(8)、对羟基苯甲酸甲酯(9)、2⁃(2⁃羟基⁃1⁃甲基⁃2⁃苯基)⁃4,5⁃二甲氧基苯酚(10)、2⁃甲氧基⁃3⁃羟基口山酮(11)、对苯二甲酸二丁酯(12)、6,4′⁃二羟基⁃7⁃甲氧基黄烷(13)、pteroyanin G(14)、benzoic acid,4⁃ethoxy⁃2⁃methoxy⁃,methyl ester(15)、甘草素(16)、4,2′,5′⁃三羟基⁃4′⁃甲氧基查尔酮(17)、7⁃羟基⁃6⁃甲氧基黄酮(18)、6,4′⁃二羟基⁃7⁃甲氧基二羟黄酮(19)、2′⁃羟基芒柄花黄素(20)、3′⁃甲氧基芒柄花黄素(21)、3′⁃羟基芒柄花黄素(22)、6,7,4′⁃三羟基二氢黄酮(23)。结论化合物2、4为首次从黄檀属植物分离得到。化合物6~8、19、21为首次从该植物分离得到。AIM To study the chemical constituents from the heartwood of Dalbergia cochinchinensis Pierre ex Laness.METHODS The 70%ethanol extract from the heartwood of D.cochinchinensis was isolated and purified by silica gel,Sephadex LH⁃20 and semi⁃preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULT Twenty⁃three compounds were isolated and identified as 3⁃O⁃acetylbetulin aldehyde(1),2,2′⁃oxybis(1,4⁃di⁃tert⁃butylbenzene)(2),ethyl 4⁃hydroxybenzoate(3),1⁃acetyl⁃β⁃carboline(4),7⁃hydroxydihydroflavone(5),palmic acid(6),hexadeca⁃4,7⁃diene(7),linoleic acid(8),methyl 4⁃hydroxybenzoate(9),2⁃(2⁃hydroxy⁃1⁃methyl⁃2⁃phenythyl)⁃4,5⁃dimethoxyphenol(10),2⁃methoxy⁃3⁃hydroxyxanthone(11),dibutyl terephthalate(12),6,4′⁃dihydroxy⁃7⁃methoxyflavan(13),pteroyanin G(14),benzoic acid,4⁃ethoxy⁃2⁃methoxy⁃,methyl ester(15),liquiritigenin(16),4,2′,5′⁃trihydroxy⁃4′⁃methoxychalcone(17),7⁃hydroxy⁃6⁃methoxyflavone(18),6,4′⁃dihydroxy⁃7⁃methoxyflavone(19),2′⁃hydroxyformonetin(20),3′⁃methoxyformonetin(21),3′⁃hydroxyformonetin(22),6,7,4′⁃trihydroxyflavanone(23).CONCLUSION Compounds 2,4 are isolated from genus Dalbergia for the first time.Compounds 6-8,19,21 are isolated from this plant for the first time.

关 键 词：交趾黄檀 心材 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]