尖海龙共附生真菌Talaromyces amestolkiae次生代谢产物的研究  

Secondary metabolites from symbiotic fungi Talaromyces amestolkiae of Syngnathus acus

作　　者：雷力荣 金梦莹 郭大乐[1] 邓赟[1] LEI Li-rong;JIN Meng-ying;GUO Da-le;DENG Yun(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《中成药》2023年第12期3994-3999,共6页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金面上项目(81973460);四川省重点研发项目(2021YFN0134)。

摘　　要：目的研究尖海龙共附生真菌Talaromyces amestolkiae的次生代谢产物。方法Talaromyces amestolkiae发酵物的甲醇提取物采用硅胶、Sephdex-LH-20、TLC、制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为2,4-bis(1,1-dimethylethyl)benzeneethanol(1)、aspergillumarins A(2)、peniciisocoumarins H(3)、2-(2-hydroxypropyl)-5-methyl-7-hydroxychromone(4)、6-demethylvermistatin(5)、penicimarin B(6)、penicimarin C(7)、8-hydroxy-6-methoxy-3-methylisocoumarin(8)、polygonolide(9)、灵芝嘌呤(10)。结论化合物1为新天然产物,化合物3~5、8~10为首次从该菌中分离得到。AIM To study the secondary metabolites from symbiotic fungi Talaromyces amestolkiae of Syngnathus acus Linnaeus.METHODS The methanol extract from Talaromyces amestolkiae fermentation was isolated and purified by silica gel,Sephadex LH-20,TLC and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as 2,4-bis(1,1-dimethylethyl)benzeneethanol(1),aspergillumarins A(2),peniciisocoumarins H(3),2-(2-hydroxypropyl)-5-methyl-7-hydroxychromone(4),6-demethylvermistatin(5),penicimarin B(6),penicimarin C(7),8-hydroxy-6-methoxy-3-methylisocoumarin(8),polygonolide(9),ganoderpurine(10).CONCLUSION Compound 1 is a new natural product.Compounds 3-5,8-10 are isolated from this fungi for the first time.

关 键 词：尖海龙 共附生真菌 Talaromyces amestolkiae 次生代谢产物 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]