复合微生态制剂对公犊牛肾阳虚功能性腹泻疗效观察  

Observation on the Effect of Compound Microecological Preparation on Functional Diarrhea of Male Calves with Kidney-yang Deficiency

作　　者：马尚杰 马强 张晋 Ma Shangjie;Ma Qiang;Zhang Jin(Gansu Livestock Breeding and Improvement Management Station,Wuwei,733000,Gansu)

机构地区：[1]甘肃省家畜繁育改良管理站,甘肃武威733000

出　　处：《中国畜禽种业》2023年第11期129-132,共4页The Chinese Livestock and Poultry Breeding

基　　金：甘肃省科学技术厅科技特派员(基地)专项项目:中小规模肉牛场高效繁育提质增效科技特派示范(23CXNH0021);甘肃省农业农村厅科技项目:种公牛健康养殖与高效利用技术集成与应用(GNKJ-2023-37);武威市市级科技人才和科学普及计划—科技特派员专题项目:复合微生态制剂防控犊牛腹泻技术研究与应用(WW2202RPT048);武威市市级科技计划B类项目:草食性家畜粪便高效利用技术研究与应用(WW23B02NY114)。

摘　　要：该试验通过注射氢化可的松建立肾阳虚公犊牛模型,研究微生态制剂对公犊牛肾阳虚功能性腹泻病临床疗效。试验选用72头健康公犊牛,随机分为6组,分别为对照组(不注射氢化可的松)、复合微生态制剂低(5.1g/kg)、中(10.2g/kg)、高(15.3g/kg)剂量组、单一微生态制剂组(20.4g/kg枯草芽孢杆菌)和模型组;灌服50d后摘取肾脏、睾丸、丘脑称重。结果表明:模型组与空白组相比体重显著降低(P<0.05),高剂量组与单一组相比,体重显著升高(P<0.05),模型组与空白组相比体温差显著降低(P<0.05)。模型组下丘脑和垂体脏器系数均高于对照组(P<0.05),下丘脑和垂体脏器系数明显偏高(P<0.05)。第50天时复合微生态制中剂量试验组与对照组相比,腹泻率降低,但低剂量、高剂量组高于对照组,低于单一组和模型组。可见,复合微生态制剂与单一枯草芽孢杆菌制剂均通过增加丘脑、垂体和自身质量并调节体温,改善机体丘脑-垂体-睾丸轴的功能,从而改善雄性公犊牛肾阳虚功能性腹泻临床症状。复合微生态制剂给药量为10.2g/(kg·d)时能明显治疗肾阳虚功能性腹泻。Establishing a Kidney Yang deficiency male calf model by injecting hydrocortisone,this study investigated the clinical effect of microecological preparation on kidney-yang deficiency functional diarrhea of male calves.compound microecological preparation[low(5.1g/kg),medium(10.2g/kg)and high(15.3g/kg)]dose group,single microecological preparation group(20.4g/kg Bacillus subtilis)and model group(25mg/kg hydrocortisone).After 50 days of administration,kidneys,testis and thalamus were removed and weighed.Results:Compared with the blank group,the body weight of the model group decreased significantly(P<0.05).Compared with the single group,the body weight of the high-dose group increased significantly(P<0.05).Compared with the blank group,the body temperature difference of the model group decreased significantly(P<0.05).The organ coefficients of thalamus and pituitary in the model group were significantly higher than those in the control group(P<0.05),and the organ coefficients of hypothalamus and pituitary were significantly higher than those in the control group(P<0.05).On the 50 th day,the diarrhea rate of the middle dose experimental group was lower than that of the control group,but the low dose and high dose groups were higher than the control group,but lower than the single group and the model group.Both the compound microecological preparation and the single Bacillus subtilis preparation can improve the function of the hypothalamic pituitary testicular axis by increasing the mass of the thalamus,pituitary gland,and body,and regulating body temperature,thereby improving the clinical symptoms of kidney yang deficiency functional diarrhea in male calves.The compound microecological preparation can obviously treat functional diarrhea with the deficiency of kidney Yang when the dosage is 10.2g/(kg·d).

关 键 词：肾阳虚 功能性腹泻 复合微生态制剂 

分 类 号：S858.23[农业科学—临床兽医学]