促红细胞生成素联合常规疗法治疗早产儿贫血的效果  

Effects of Erythropoietin combined with conventional therapy on anemia in premature infants

作　　者：张寅[1] ZHANG Yin(Rooming-in Care of Shangqiu First People’s Hospital,Shangqiu 476100 Henan,China)

机构地区：[1]商丘市第一人民医院新生儿母婴同室,河南商丘476100

出　　处：《中国民康医学》2023年第23期87-89,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察促红细胞生成素联合常规疗法治疗早产儿贫血的效果。方法:回顾性分析2021年1月至2023年2月该院收治的94例贫血早产儿的临床资料,按照治疗方案不同将其分为对照组与研究组各47例。对照组予以常规疗法(铁剂+维生素)治疗,研究组在对照组基础上联合促红细胞生成素治疗。比较两组临床疗效,治疗前后血常规指标[网织红细胞(Ret)百分比、血红蛋白(Hb)、铁蛋白(SF)]水平、神经行为发育[格赛尔发育量表(Gesell)]评分、血清白细胞介素-17(IL-17)水平、血清白细胞介素-23(IL-23)水平、不良反应率和治疗期间输血率。结果:研究组治疗总有效率为97.87%(46/47),高于对照组的82.98%(39/47),差异有统计学意义(P<0.05);治疗后,研究组Ret百分比,Hb、SF水平,以及Gesell评分均高于对照组,差异有统计学意义(P<0.05);治疗后,研究组血清IL-17、IL-23水平均低于对照组,差异有统计学意义(P<0.05);研究组治疗期间输血率为17.02%(8/47),低于对照组的36.17%(17/47),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:促红细胞生成素联合常规疗法治疗早产儿贫血可提高治疗总有效率和神经行为发育评分,改善血常规指标水平,降低输血率和IL-17、IL-23水平,效果优于单纯常规疗法治疗。Objective:To observe effects of Erythropoietin combined with conventional therapy on anemia in premature infants.Methods:The clinical data of 94 premature infants with anemia admitted to this hospital from January 2021 to February 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,47 cases in each.The control group was treated with conventional therapy(iron supplements+Vitamin),while the study group was treated with Erythropoietin on the basis of that of the control group.The clinical efficacy,the blood routine indexes[reticulocyte(Ret)percentage,hemoglobin(Hb),ferritin(SF)]levels,the neurobehavioral development[Gesell development scale(Gesell)]score,the serum interleukin-17(IL-17)level,the serum interleukin-23(IL-23)level,the incidence of adverse reactions,and the blood transfusion rate during the treatment were compared between the two groups.Results:The total effective rate of treatment in the study group was 97.87%(46/47),which was higher than 82.98%(39/47)in the control group,and the difference was statistically significant(P<0.05).After treatment,the Ret percentage,the levels of Hb,SF and the Gesell score in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum IL-17 and IL-23 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The blood transfusion rate during treatment in the study group was 17.02%(8/47),which was lower than 36.17%(17/47)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Erythropoietin combined with conventional therapy in the treatment of anemia in the premature infants can improve the total effective rate of treatment and the neurobehavioral development scores,improve the levels of blood routin

关 键 词：促红细胞生成素 早产儿贫血 血常规 神经行为发育 输血率 白细胞介素 不良反应 

分 类 号：R722.6[医药卫生—儿科]