宫外孕方剂联合氨甲蝶呤治疗输卵管妊娠患者的效果  

Effects of ectopic pregnancy prescription combined with Methotrexate in treatment of patients with tubal pregnancy

作　　者：刘志惠[1] 蔡芳[1] 刘平[1] LIU Zhihui;CAI Fang;LIU Ping(Department of Obstetrics and Gynecology of Nanyang Second General Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市第二人民医院妇产科,河南南阳473000

出　　处：《中国民康医学》2023年第23期121-124,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察宫外孕方剂联合氨甲蝶呤治疗输卵管妊娠患者的效果。方法:选取2021年2月至2022年4月该院收治的104例输卵管妊娠患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各52例。对照组采用氨甲蝶呤治疗,观察组在对照组基础上联合宫外孕方剂治疗,比较两组临床疗效、治疗前后卵巢储备功能指标[黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E_(2))]水平、症状缓解/消失时间、疾病相关指标[糖类抗原125(CA125)、孕酮、血管内皮生长因子(VEGF)]水平和不良反应发生率。结果:观察组治疗总有效率为98.08%(51/52),高于对照组的80.77%(42/52),差异有统计学意义(P<0.05);治疗后,两组LH、FSH、E_(2)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组住院时间、腹痛消失时间、血β-人绒毛膜促性腺激素恢复正常时间、妊娠包块消失时间、阴道流血消失时间均短于对照组,差异有统计学意义(P<0.05);两组CA125、孕酮、VEGF水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:宫外孕方剂联合氨甲蝶呤治疗输卵管妊娠患者可提高治疗总有效率,缩短症状缓解/消失时间,降低卵巢储备功能指标和疾病相关指标水平,其效果优于单纯氨甲蝶呤治疗。Objective:To observe effects of ectopic pregnancy prescription combined with Methotrexate in treatment of patients with tubal pregnancy.Methods:A prospective study was conducted on 104 patients with tubal pregnancy admitted to the hospital from February 2021 to April 2022.They were divided into control group and observation group according to the random number table method,52 cases in each group.The control group was treated with Methotrexate,while the observation group was treated with ectopic pregnancy prescription on the basis of that of the control group.The clinical efficacy,the ovarian reserve function index levels[luteinizing hormone(LH),follicle estrogen(FSH),estradiol(E_(2))]before and after the treatment,the symptom relief/disappearance time,the disease-related indexes[carbohydrate antigen 125(CA125),progesterone,vascular endothelial growth factor(VEGF)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 98.08%(51/52),which was higher than 80.77%(42/52)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LH,FSH and E_(2) in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The hospitalization time,the disappearance time of abdominal pain,the recovery time of blood beta human chorionic gonadotropin,the disappearance time of pregnancy mass and the disappearance time of vaginal bleeding in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The levels of CA125,progesterone and VEGF in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse rea

关 键 词：输卵管妊娠 氨甲蝶呤 宫外孕方剂 卵巢储备功能 不良反应 

分 类 号：R714.22[医药卫生—妇产科学]