归脾汤加味治疗气不摄血型原发免疫性血小板减少症的临床疗效研究  

Clinical efficacy of Guipi Decoction in treating primary immune thrombocytopenia(Qi dysfunction in blood control)

作　　者：荆徐波 JING Xu-bo(Department of Neurology and Hematology,Heyang County People's Hospital,Weinan 715300,China)

机构地区：[1]合阳县人民医院神经内一血液科,715300

出　　处：《中国实用医药》2023年第23期33-37,共5页China Practical Medicine

摘　　要：目的 观察归脾汤加味治疗气不摄血型原发免疫性血小板减少症(ITP)的临床疗效。方法 60例气不摄血型ITP患者,随机分为对照组和治疗组,每组30例。对照组选用醋酸泼尼松治疗,治疗组在对照组基础上加用中药汤剂(归脾汤加味)治疗。比较两组中西医疗效、起效时间、血小板变化、安全性指标及不良反应发生率。结果 治疗组西医治疗总有效率93.33%高于对照组的83.33%,但差异无统计学意义(P>0.05)。治疗组西医临床疗效起效时间(15.967±5.262)d显著短于对照组的(20.533±6.862)d,差异有统计学意义(P<0.05)。治疗组中医证候总有效率96.67%明显高于对照组的70.00%,差异有统计学意义(P<0.05)。治疗组中医证候疗效起效时间(14.700±5.312)d显著短于对照组的(19.367±6.283)d,差异有统计学意义(P<0.05)。治疗前后,两组组间血小板计数比较,差异无统计学意义(P>0.05)。治疗后,治疗组血小板计数为(79.500±30.081)×10^(9)/L,对照组为(66.367±31.250)×10^(9)/L均明显高于本组治疗前的(31.733±9.472)×10^(9)/L、(31.867±7.902)×10^(9)/L,差异有统计学意义(P<0.05)。两组血糖、血压、肝肾功能、心电图、下腹部超声、凝血四项及尿粪常规未发现明显不良影响。治疗组不良反应主要是心悸(13.33%)、恶心(20.00%)、头晕(10.00%),不良反应较少;对照组不良反应主要是食欲亢进(33.33%)、心悸(30.00%)、恶心(30.00%)、头晕(23.33%)、体重增加(20.00%)、多毛症(16.67%),不良反应较多。结论 中西医结合治疗气不摄血型ITP综合疗效明显优于单纯激素治疗。Objective To observe the clinical efficacy of Guipi Decoction in treating primary immune thrombocytopenia(ITP,Qi dysfunction in blood control).Methods A total of 60 patients with ITP(Qi dysfunction in blood control)were randomly divided into a control group and a treatment group,with 30 cases in each group.The control group was treated with prednisone acetate,and the treatment group was treated with traditional Chinese medicine Decoction(modifed Guipi Decoction)on the basis of the control group.The efficacy,onset time,platelet changes,safety indexes and incidence of adverse reactions were compared between the two groups.Results The total effective rate of Western medicine treatment in the treatment group was 93.33%,which was higher than that of 83.33%in the control group,but the difference was not statistically significant(P>0.05).The onset time of clinical efficacy of Western medicine in the treatment group was(15.967±5.262)d,which was significantly shorter than that of(20.533±6.862)d in the control group,and the difference was statistically significant(P<0.05).The total effective rate of traditional Chinese medicine syndrome in the treatment group was 96.67%,which was higher than that of 70.00%in the control group,and the difference was statistically significant(P<0.05).The onset time of efficacy of traditional Chinese medicine syndrome in the treatment group was(14.700±5.312)d,which was significantly shorter than that of(19.367±6.283)d in the control group,and the difference was statistically significant(P<0.05).Before and after treatment,there was no statistically significant difference in platelet count between the two groups(P>0.05).After treatment,the platelet count of the treatment group was(79.500±30.081)×10^(9)/L,and that of the control group was(66.367±31.250)×10^(9)/L,which were significantly higher than those of(31.733±9.472)×10^(9)/L and(31.867±7.902)×10^(9)/L before treatment in this group.The difference were statistically significant(P<0.05).No significant adverse effects were found in

关 键 词：归脾汤 原发免疫性血小板减少症 气不摄血型 

分 类 号：R259[医药卫生—中西医结合]