化疗联合放疗对直肠癌术后患者临床疗效及生活质量的影响  

Influence of chemotherapy combined with radiotherapy on clinical efficacy and quality of life of patients after rectal cancer surgery

作　　者：陈志平 曹海英 胡爱玲 沙晓锋 CHEN Zhi-ping;CAO Hai-ying;HU Ai-ling(Hongze District People's Hospital,Huai'an 223100,China)

机构地区：[1]江苏省淮安市洪泽区人民医院,223100

出　　处：《中国实用医药》2023年第23期97-100,共4页China Practical Medicine

摘　　要：目的 研究化疗联合放疗对直肠癌术后患者临床疗效及生活质量的影响。方法 80例直肠癌术后患者,依据交替分组法分成观察组及对照组,各40例。对照组术后采取放疗治疗,观察组术后实施化疗联合放疗治疗。比较两组患者治疗后的近期疗效、远期疗效及生存质量评分,治疗前后的健康状况评分及肿瘤标记物[糖类抗原125(CA125)、糖类抗原242(CA242)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)]水平。结果 治疗后,观察组患者的疾病缓解率92.50%高于对照组的75.00%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的躯体功能、角色功能、情绪功能、社会功能、认知功能评分分别为(17.34±2.25)、(16.84±2.35)、(16.95±2.85)、(15.75±2.95)、(17.45±2.36)分,均高于对照组的(13.66±2.47)、(12.56±2.15)、(12.54±2.66)、(11.23±1.86)、(12.57±2.24)分,差异具有统计学意义(P<0.05)。治疗后,两组患者的卡氏量表(KPS)评分均高于本组治疗前,且观察组患者的KPS评分(60.51±7.24)分高于对照组的(52.38±6.92)分,差异具有统计学意义(P<0.05)。治疗后,观察组患者的CA125、CA242、CEA、CA19-9水平分别为(13.21±4.23)U/ml、(62.75±13.76)ng/ml、(12.57±2.68)ng/ml、(32.12±6.05)U/ml,均低于对照组的(18.23±3.57)U/ml、(83.72±15.49)ng/ml、(19.92±3.17)ng/ml、(37.63±5.86)U/ml,差异具有统计学意义(P<0.05)。随访2年,观察组患者的无病生存率82.50%、总生存率92.50%均高于对照组的60.00%、72.50%,疾病复发率2.50%低于对照组的15.00%,差异具有统计学意义(P<0.05)。结论 直肠癌术后患者采用放疗联合化疗的治疗方式可更好的抑制癌细胞,提升患者的临床疗效及生活质量。Objective To study the influence of chemotherapy combined with radiotherapy on clinical efficacy and quality of life of patients after rectal cancer surgery.Methods A total of 80 patients after rectal cancer surgery were divided into an observation group and a control group according to alternate grouping method,with 40 cases in each group.The control group received postoperative radiotherapy,and the observation group received postoperative chemotherapy combined with radiotherapy.Both groups were compared in terms of short-term efficacy,long-term efficacy and quality of life score after treatment,health status scores and the levels of tumor markers[carbohydrate antigen 125(CA125),carbohydrate antigen 242(CA242),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)]before and after treatment.Results After treatment,the disease remission rate of 92.50%in the observation group was higher than that of 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of physical function,role function,emotional function,social function and cognitive function in the observation group were(17.34±2.25),(16.84±2.35),(16.95±2.85),(15.75±2.95)and(17.45±2.36)points,which were higher than those of(13.66±2.47),(12.56±2.15),(12.54±2.66),(11.23±1.86)and(12.57±2.24)points in the control group,and the differences were statistically significant(P<0.05).After treatment,Karnofsky performance status(KPS)score in both groups were higher than that before treatment in this group,and KPS score of(60.51±7.24)points in the observation group were higher than that of(52.38±6.92)points in the control group.The differences were statistically significant(P<0.05).After treatment,the levels of CA125,CA242,CEA and CA19-9 in the observation group were(13.21±4.23)U/ml,(62.75±13.76)ng/ml,(12.57±2.68)ng/ml and(32.12±6.05)U/ml,which were lower than those of(18.23±3.57)U/ml,(83.72±15.49)ng/ml,(19.92±3.17)ng/ml and(37.63±5.86)U/ml in the control group,and the differences were stati

关 键 词：化疗 放疗 直肠癌术后 临床疗效 生活质量 

分 类 号：R735.37[医药卫生—肿瘤]