基于正邪理论探讨巨噬细胞极化在动脉粥样硬化过程中的作用  

The role of macrophage polarization in the process of atherosclerosis based on the theory of Zheng and Xie

作　　者：胡伊蕾 马至言 周曼丽 高翎薇 简维雄 蔡磊[1] HU Yilei;MA Zhiyan;ZHOU Manli;GAO Lingwei;JIAN Weixiong;CAI Lei(College of Chinese Medicine,Hunan University of Chinese Medicine;National Key Discipline of TCM Diagnositics,Hunan Provincial Key Laboratory,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学中医学院 [2]湖南中医药大学国家重点学科中医诊断学湖南省重点实验室,湖南省长沙市410208

出　　处：《中国动脉硬化杂志》2023年第12期1084-1090,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81973753);湖南省自然科学基金项目(2022JJ30433);湖南省研究生科研创新项目(CX20220781)。

摘　　要：巨噬细胞是一类与动脉粥样硬化(As)密切相关的免疫细胞,随着机体内环境的变化,巨噬细胞会极化成不同表型。在生理环境下,巨噬细胞极化处于动态平衡;在As的状态下,极化平衡遭到破坏,分化出相应表型的巨噬细胞,在As各环节起不同作用。正邪交争存在于As形成发展的全过程,而巨噬细胞极化贯穿于As证型变化的全阶段。基于此,该综述通过正邪理论探讨巨噬细胞极化与As之间的关联,提出临床防治As应注意宏观结合微观,并可通过调控巨噬细胞极化,控制炎症反应、稳定斑块,为As的中医药治疗提供新兴靶点。Macrophage is a kind of immune cell which is closely related to atherosclerosis(As).With the change of internal environment,macrophage can polarize into different phenotype.Under the physiological environment,the polarization of macrophages is in dynamic balance.In the As state,the polarization balance is destroyed and the corresponding phenotypic macrophages are differentiated,which play different roles in each stage of As.The debate between Zheng and Xie exists in the whole process of As formation and development,while macrophage polarization runs through the whole stage of As syndrome differentiation and change.On account of this,this paper discusses the relationship between macrophage polarization and As based on the theory of Zheng and Xie,and propose that attention should be paid to the combination of macro and micro in the clinical prevention and treatment of As,and it can control the inflammatory response and stabilize plaque by regulating the macrophage polarization,thus providing an emerging target for the treatment of As with traditional Chinese medicine.

关 键 词：动脉粥样硬化 巨噬细胞极化 正邪理论 

分 类 号：R5[医药卫生—内科学]