维生素D与自身免疫性甲状腺疾病的研究进展  

Research Progress of Vitamin D and Autoimmune Thyroid Disease

作　　者：宋静静 樊琳琳[2] SONG Jingjing;FAN Linlin(Clinical Medical College of Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272067 [2]山东省济宁市第一人民医院

出　　处：《中国医学创新》2023年第35期182-188,共7页Medical Innovation of China

摘　　要：维生素D缺乏普遍存在于人群中,维生素D的经典作用与骨骼、肾脏和肠道有关。近年来研究发现,维生素D还与免疫、生殖、内分泌、肌肉及大脑、皮肤和肝脏相关。维生素D与自身免疫性甲状腺疾病(autoimmune thyroid disease,AITD)之间的关系也被广泛研究,但只有少数在人类中进行的随机临床试验研究了维生素D在预防或治疗免疫性疾病中的可能作用。本文的目的是回顾最近维生素D与AITD之间的文献,分析其可能存在的机制,以及补充维生素D在AITD中的潜在意义。Vitamin D deficiency is common in humans,and the classic effects of vitamin D are related to the bones,kidneys and intestines.In recent years,studies had found that vitamin D is also associated with immunity,reproduction,endocrine,muscle,brain,skin and liver.The relationship between vitamin D and autoimmune thyroid disease(AITD)has also been extensively studied,but only a handful of randomized clinical trials in humans have investigated the possible role of vitamin D in the prevention or treatment of immune diseases.The aim of this article was to review the recent literature on vitamin D and AITD,to analyze its possible mechanisms,and supplement the potential significance of vitamin D in AITD.

关 键 词：维生素D 自身免疫性甲状腺疾病 桥本甲状腺炎 格雷夫斯病 格雷夫斯眼病 

分 类 号：R581[医药卫生—内分泌]