围生期孕妇感染B族链球菌血清型与不良妊娠结局的关系  

Relationship between serotypes of group B Streptococcus infection in perinatalpregnant women and adverse pregnancy outcomes

作　　者：贾丽娜[1] 佘欣 JIA Lina;SHE Xin(Department of Clinical Laboratory,Affiliated Hospital of Guilin Medical University,Guilin,Guangxi 541001,China)

机构地区：[1]桂林医学院附属医院检验科,广西桂林541001

出　　处：《检验医学与临床》2023年第24期3603-3606,共4页Laboratory Medicine and Clinic

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190597)。

摘　　要：目的 了解围生期孕妇生殖道B族链球菌(GBS)感染率,探讨GBS感染状况及其血清型与不良妊娠结局的关系。方法 选择2019年7月至2020年12月在该院建卡产检并分娩的1 294例围生期孕妇作为研究对象,在入院时进行阴道分泌物GBS培养,GBS培养阳性者再进行GBS血清型分型。将GBS阳性孕妇作为阳性组,按1∶3比例随机抽取GBS阴性孕妇作为阴性组,比较两组孕妇的不良妊娠结局发生情况,并分析不良妊娠结局孕妇感染GBS血清型的分布情况。结果 GBS培养阳性75例,阳性组孕妇共75例,阴性组孕妇共225例。围生期孕妇生殖道GBS感染率为5.80%(75/1 294)。阳性组孕妇胎膜早破和产后出血发生率分别为30.67%和6.67%,均高于阴性组(16.89%、1.33%),差异均有统计学意义(P<0.05);两组早产、胎儿窘迫和绒毛膜羊膜炎发生率比较,差异均无统计学意义(P>0.05)。阳性组中23例胎膜早破孕妇感染Ⅲ型GBS的比例最高,占60.87%,其次是Ⅰb型(26.09%)和Ⅰa型(13.04%);5例产后出血孕妇感染Ⅰb型GBS的比例最高,占60.00%,Ⅰa型和Ⅲ型均占20.00%。阳性组感染Ⅰb型和Ⅲ型GBS的孕妇不良妊娠结局发生率分别为60.00%(12/20)和54.84%(17/31),均高于Ⅰa型[25.00%(6/24)],差异有统计学意义(P<0.05)。结论 GBS感染增加了围生期孕妇胎膜早破、产后出血等不良妊娠结局的发生率,感染Ⅲ型和Ⅰb型GBS孕妇的不良妊娠结局发生率更高,临床需加强对孕妇的健康宣教,重视围生期孕妇生殖道GBS及其血清型筛查并及时进行干预,可预防GBS感染,改善孕妇的妊娠结局。Objective To understand the infection rate of group B Streptococcus(GBS)in the reproductive tract of perinatal pregnant women,and to explore the GBS infection status and the relationship between its serotypes and adverse pregnancy outcomes.Methods A total of 1294 perinatal pregnant women who established the card for conducting the prenatal examination and delivered in this hospital from July 2019 to December 2020 were selected as the research subjects.Their vaginal secretions conducted the GBS bacterial culture at admission,and the subjects with GBS culture positive conducted the GBS serotyping.The pregnant women with GBS positive were included in the positive group,and the GBS negative pregnant women were randomly extracted with 1∶3 ratio as the negative group.The adverse pregnancy outcomes were compared between the two groups,and the distribution situation of GBS infection serotypes in pregnant women with adverse pregnancy outcomes was analyzed.Results There were 75 cases of GBS culture positive.The positive group had 75 pregnant women and negative group had 225 pregnant women.The infection rate of GBS in the reproductive tract of perinatal pregnant women was 5.80%(75/1294).The incidence rates of premature rupture of membranes and postpartum hemorrhage in pregnant women of the positive group were 30.67%and 6.67%,respectively,which were higher than those in the negative group(16.89%,1.33%),and the differences were statistically significant(P<0.05);There was no statistically significant difference in the incidence rates of premature birth,fetal distress and chorioamnionitis between the two groups(P>0.05).Among 23 pregnant women with premature rupture of membranes in the positive group,the proportion of typeⅢGBS infection was the highest,accounting for 60.87%,followed by typeⅠb(26.09%)and typeⅠa(13.04%);the proportion of typeⅠb GBS infection among 5 pregnant women with postpartum hemorrhage was the highest,accounting for 60.00%,which of both typesⅠa andⅢaccounted for 20.00%.The incidence rates of adv

关 键 词：围生期 B族链球菌 感染 血清型 不良妊娠结局 

分 类 号：R446.5[医药卫生—诊断学]