辣椒素对心血管疾病防治作用的研究进展  

Research progress on role of capsaicin in prevention and treatment of cardiovascular diseases

作　　者：鞠洪远 李克柔 董英伟[1] JU Hong-yuan;LI Ke-rou;DONG Ying-wei(Department of Anesthesiology,First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院麻醉科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第一医院内分泌科,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2023年第6期645-649,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：辣椒素(CAP)是辣椒的提取物,是香草素类化合物的成员,对预防和治疗心血管疾病有着重要价值。受体瞬时感受器电位香草酸受体(TRPV)1是CAP的特异性受体,广泛表达于神经系统、心血管系统等。近年来有大量研究表明,CAP通过激活TRPV1,释放多种神经肽类物质,并通过多条信号通路保护心血管系统。本文就CAP的药理作用及其对心血管疾病防治作用的研究进展作一综述,旨在为心血管疾病的预防和治疗提供新思路。Capsaicin(CAP)is an extract of capsicum,a member of vanillin compounds,which possesses important value in prevention and treatment of cardiovascular diseases.Transient receptor potential vanilloid(TRPV)1 is a specific receptor of CAP,widely expressed in nervous system,cardiovascular system etc.In recent years,a large number of studies have indicated that CAP protects cardiovascular system by activating TRPV1,releasing a variety of neuropeptides through multiple signaling pathways.The present article makes a review on pharmacological action of CAP and its role in prevention and treatment of cardiovascular diseases,aiming at providing new thinking for prevention and treatment of cardiovascular diseases.

关 键 词：心血管疾病 香草酸 神经肽类 

分 类 号：R54[医药卫生—心血管疾病]