Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma  

作　　者：Zhiyu Chen Fang Li Lei Fu Yu Xia Ying Luo Ang Guo Xiaona Zhu Huifang Zhong Qian Luo 

机构地区：[1]Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Rheumatology&Immunology Department of Shenzhen Children’s Hospital,Shenzhen 518038,China [4]Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances,Institute of Environment and Health,Jianghan University,Wuhan 430056,China

出　　处：《Journal of Environmental Sciences》2024年第3期172-180,共9页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos.22076197,21707149 and 82127801);the Scientific Instrument Developing Project of the Chinese Academy of Sciences (No.YJKYYQ20200034);Shenzhen Science and Technology Research Funding (Nos.JCYJ20210324115811031 and JCYJ20200109115405930);Guangdong Basic and Applied Basic Research Foundation (No.2020B1515120080)。

摘　　要：Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the disease.We have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)children.Eight PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,respectively.Moreover,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as control.Thirty-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and TNBP.These results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关 键 词：Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation 

分 类 号：X503[环境科学与工程—环境工程] R725.6[医药卫生—儿科]