RDW、LDH、α-HBDH联合应用对肺纤维化患者的诊断价值  

Diagnostic significance of combination of RDW,LDH andα-HBDH in pulmonary fibrosis

作　　者：康凯 延萌萌 刘乃国[1] KANG Kai;YAN Mengmeng;LIU Naiguo(Medical Reasearch Center,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China;Zhangqiu People′s Hospital of Jinan,Jinan 250299,Shandong,P.R.China)

机构地区：[1]滨州医学院附属医院医学研究中心,山东滨州256603 [2]济南市章丘区人民医院,山东济南250299

出　　处：《滨州医学院学报》2023年第6期430-433,共4页Journal of Binzhou Medical University

基　　金：山东省自然科学基金(ZR2019MC019)。

摘　　要：目的探讨红细胞分布宽度(RDW)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)联合应用在肺纤维化中的诊断价值。方法选取肺纤维化患者138例为肺纤维化组,老年肺炎患者177例为老年肺炎组,同时选取体检健康者61例为对照组,检测三组成员的血液中RDW、LDH、α-HBDH的含量。用Kruskal-Wsllis非参数检验分析RDW、LDH、α-HBDH对肺纤维化的诊断价值。结果肺纤维化患者血液中RDW、LDH和α-HBDH的水平均明显高于老年肺炎患者和健康体检者,P<0.05。对肺纤维化患者一次入院、二次入院和健康体检者血液中RDW、LDH、α-HBDH的水平进行比较,P<0.05。RDW、LDH、α-HBDH联合诊断肺纤维化的ROC曲线下面积(AUC)为0.832,高于各项指标单独检测0.76、0.695、0.753。结论RDW、LDH、α-HBDH对肺纤维化都具有一定的诊断价值,三个指标联合使用可以使诊断结果更加准确。Objective To investigate the diagnostic value of the combination of red blood cell distribution width(RDW),lactate dehydrogenase(LDH),and alpha-Hydroxybutyrate-dehydrogenase(α-HBDH)in pulmonary fibrosis.Methods One hundred and thirty-eight patients with pulmonary fibrosis were selected as the fibrosis group,177 senile patients with pneumonia as the senile pneumonia group,and 61 healthy people as the control group.The levels of RDW,LDH andα-HBDH in the blood of the three groups were detected.The diagnostic value of RDW,LDH andα-HBDH in pulmonary fibrosis was analyzed by the Kruskal-Wsllis nonparametric test.Results The levels of RDW,LDH andα-HBDH in the blood of patients with pulmonary fibrosis were significantly higher than those of senile patients with pneumonia and healthy persons(P<0.05),and the differences were statistically significant(P<0.05).There were statistical differences about RDW,LDH and α-HBDH among the first admission of patients with pulmonary fibrosis,the second admission of patients with pulmonary fibrosis and the health people,and the differences were statistically significant(P<0.05).The area under the ROC curve(AUC)was 0.832 for the combination of RDW,LDH and α-HBDH in the diagnosis of pulmonary fibrosis,which was higher than each index detected separately 0.76,0.695 and 0.753.Conclusion RDW,LDH andα-HBDH have certain diagnostic value in pulmonary fibrosis,and the combined use of the three indexes can make the diagnosis more accurate.

关 键 词：红细胞分布宽度 乳酸脱氢酶 Α-羟丁酸脱氢酶 肺纤维化 诊断 

分 类 号：R563.9[医药卫生—呼吸系统]