积雪苷霜联合负压封闭引流术在深度烧伤患者创面修复中的应用  

Effect of asiaticoside cream combined with vacuum sealing drainage regimen in wound repair of patients with deep burns

作　　者：王永美[1] 崔雪琴 刘瑜[2] 张友来[1] 戴小华[1] WANG Yongmei;CUI Xueqin;LIU Yu;ZHANG Youlai;DAI Xiaohua(Department of Burns,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi P.R.China;General Surgery,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi P.R.China)

机构地区：[1]南昌大学第一附属医院烧伤科,江西南昌330006 [2]南昌大学第一附属医院普外科,江西南昌330006

出　　处：《滨州医学院学报》2023年第6期445-448,452,共5页Journal of Binzhou Medical University

基　　金：江西省中医药管理局科技计划(2021A345)。

摘　　要：目的探讨分析积雪苷霜联合负压封闭引流术(VSD)在深度烧伤患者创面修复中的应用效果。方法选取进行植皮治疗的90例深度烧伤患者,分为观察组和对照组,各45例。对照组患者给予VSD进行治疗,观察组患者在对照组的基础上联合积雪苷霜进行治疗,比较两组患者住院时间、创面愈合时间、首次植皮存活率、细菌培养阳性率、创面愈合率、并发症发生情况,负压引流后后炎性因子、疼痛介质、生活质量情况。结果观察组住院时间、创面愈合时间均低于对照组(P<0.05)。观察组患者细菌培养阳性率低于对照组,而首次植皮存活率、创面愈合率均高于对照组(P<0.05)。创面换药1周后,两组患者IL-6、TNF-α、CRP炎性因子水平和NPY、5-HT、PGE2疼痛介质水平较负压引流后降低(P<0.05),观察组较对照组更低(P<0.01)。出院时两组患者生理功能、生理职能、活力、总体健康、躯体疼痛、情感职能、社会功能、精神健康生活质量评分较负压引流后升高(P<0.05),观察组较对照组更高(P<0.05或<0.01)。观察组并发症总发生率为6.67%,对照组并发症总发生率为22.22%,观察组并发症总发生率低于对照组(P<0.05)。结论积雪苷霜联合VSD可有效促进深度烧伤患者创面愈合,减轻炎症反应和疼痛情况,促进生活质量提高,并发症少,效果显著。Objective To explore and analyze the application effect of asiaticoside cream combined with vacuum sealing drainage(VSD)in wound repair of patients with deep burns.Methods 90 patients with deep burns who underwent skin were selected and divided into an observation group and a control group,with 45 cases in each.The patients in the control group were treated with VSD,and the patients in the observation group were treated with asiaticoside cream on the basis of the control group.Skin graft survival rate,bacterial culture positive rate,wound healing rate,incidence of complications,and inflammatory factors,pain mediators,quality of life before and after treatment.Results The hospitalization day,and wound healing time in the observation group were lower than those in the control group(P<0.05).The positive rate of bacterial culture in the observation group was lower than that in the control group,while the survival rate of the first skin grafting and the wound healing rate were higher than those in the control group(P<0.05).1 week after dressing change treatment,the levels of IL-6,TNF-α,CRP inflammatory factors and NPY,5-HT,PGE2 pain mediators in the two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.01).The scores of physiological function,physiological function,vitality,overall health,physical pain,emotional function,social function,and mental health and quality of life of the two groups when discharged were higher compared with baseline(P<0.05),and the observation group was higher than the control group(P<0.05 or<0.01).The total incidence of complications in the observation group was 6.67%,and the total incidence of complications in the control group was 22.22%.The total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Asiaticoside cream combined with VSD program can effectively promote wound healing in deep burn patients,reduce inflammatory response and pain,and improve quality of li

关 键 词：积雪苷霜 负压封闭引流技术 深度烧伤 创面修复 

分 类 号：R437.6[医药卫生—临床医学]