冷自身抗体伴IgG抗-S致配血不合1例  

Blood matching incompatibility caused by cold autoantibodies and IgG anti S antibody:a case report

作　　者：马晨 MA Chen(Zibo Central Blood Station,Zibo 255000,China.)

机构地区：[1]淄博市中心血站,山东淄博255000

出　　处：《中国输血杂志》2023年第12期1165-1167,共3页Chinese Journal of Blood Transfusion

摘　　要：目的分析1例冷自身抗体伴IgG抗-S贫血患者的血清学特点。方法将患者血清与筛选细胞、自身细胞和谱细胞在室温和37℃条件下分别在盐水和抗人球蛋白卡介质中进行不规则抗体筛选,同时将破坏IgM抗体后的血清和酸放散液分别在抗人球蛋白卡介质中进行不规则抗体筛选,利用吸收放散试验处理患者红细胞和血清,排除冷自身抗体的干扰后进行不规则抗体鉴定和交叉配血。结果在此患者血清中发现冷自身抗体,并伴同种抗-S。结论当发现患者具有冷自身抗体时要仔细筛查其是否具有同种抗体,以免漏检同种抗体而引发输血后免疫反应。Objective To analyze the serological characteristics of an anemia patient with cold autoantibodies and IgG anti S antibody.Methods Unexpected antibody screening was performed on screening cells,autologous cells and panel cells with patient serum in saline and anti human globulin card media at room temperature and 37℃,respectively.At the same time,the serum that destroying IgM antibodies and acid elution solution were respectively screened for unexpected antibodies in anti human globulin card media.The absorption-elution test was used to treat patients′red blood cells and serum,and the unexpected antibody identification and cross matching were performed after excluding the interference of cold autoantibodies.Results Cold autoantibodies and IgG anti S antibody were found in the serum of this patient.Conclusion When a patient is found to have cold autoantibodies,it is necessary to screen the alloantibody,in order to avoid post transfusion immune reactions due to missed detection of alloantibody.

关 键 词：冷自身抗体 抗-S抗体 交叉配血 输血安全 

分 类 号：R457.11[医药卫生—治疗学]