过敏性紫癜及过敏性紫癜性肾炎患者中抗β2糖蛋白1抗体水平的研究  

Study on the level of antibody againstβ2 glycoprotein-1 in patients with Henoch-Sch nlein purpura and Henoch-Sch nlein purpura nephritis

作　　者：于尧 陈皓[1] 李兰英 YU Yao;CHEN Hao;LI Lanying(Tongji University Affiliated Shanghai Fourth People′s Hospital,Shanghai 200434,China)

机构地区：[1]同济大学附属上海市第四人民医院皮肤科,上海200434

出　　处：《国际检验医学杂志》2023年第S02期74-77,共4页International Journal of Laboratory Medicine

基　　金：虹口区卫生健康委员会医学科研课题计划资助(虹卫2103-05)。

摘　　要：目的通过研究比较过敏型紫癜非肾炎患者、过敏性紫癜性肾炎患者与健康人群中抗β2-GP1抗体水平变化,来明确抗β2-GP1抗体在过敏性紫癜及过敏性紫癜性肾炎发病过程中是否有相关性。同时比较抗β2-GP1抗体阳性与阴性患者中,红细胞沉降率(ESR)、C反应蛋白(CRP)水平,来明确抗β2-GP1抗体与炎症指标的相关性。方法将80例过敏性紫癜患者根据是否有肾炎,分为40例过敏性紫癜非肾炎组及40例过敏性紫癜性肾炎组。40例健康者作为健康对照组。采用酶联免疫吸附法检测,比较3组血清中抗β2-GP1抗体阳性率。并比较过敏性紫癜患者中,抗β2-GP1抗体患者与非阳性患者中ESR、CRP水平。结果过敏性紫癜非肾炎组较健康对照组抗β2-GP1抗体阳性率明显增高,差异具有统计学意义(P<0.05);过敏性紫癜性肾炎组较过敏性紫癜非肾炎组抗β2-GP1抗体阳性率明显增高,差异具有统计学意义(P<0.05)。过敏性紫癜非肾炎组及肾炎组中抗β2-GP1抗体阳性患者较抗体阴性患者的ESR、CRP水平明显增高,差异具有统计学意义(P<0.05)。结论抗β2-GP1抗体可能与过敏性紫癜及过敏性紫癜性肾炎有相关性,可能参与炎症反应。Objective By comparing the level of anti-β2-glycoprotein 1 antibody(anti-β2-Gp1 antibody)in patients with Henoch purpura non-nephritis(HSPNN),Henoch-Sch nlein purpura nephritis(HSPN)and normal population,to determine whether the anti-β2-GP1 antibody has a correlation in the pathogenesis of HSP and HSPN.Methods Eighty patients with HSP were divided into 40 patients with HSPNN group and 40 patients with HSPN group,according to whether they had nephritis.40 healthy normal subjects were used as healthy control group.Enzyme-linked immunosorbent assay was used to detect the positive rate of anti-β2-GP1 antibody in serum of 3 groups.The levels of erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)in HSP patients with positive anti-β2-GP1 antibody and non-positive anti-β2-GP1 were compared.Results The positive rate of anti-β2-GP1 antibody in HSPNN group was significantly higher than that in healthy control group,and the difference was statistically significant(P<0.05);The positive rate of anti-β2-GP1 antibody in HSPN group was significantly higher than that in HSPNN group,and the difference was statistically significant(P<0.05);The levels of ESR and CRP were significantly increased in patients with positive anti-β2-GP1 antibody,and the difference was statistically significant(P<0.05).Conclusion Anti-β2-gp1 antibody may be associated with HSP and HSPN,and may be involved in inflammatory reactions.

关 键 词：过敏性紫癜 过敏性紫癜性肾炎 抗Β2糖蛋白1抗体 

分 类 号：R692.3[医药卫生—泌尿科学]