血浆蛋白Z及凝血因子Ⅷ水平活性检测在小儿原发性肾病综合征诊断中的应用  

Application of plasma protein Z and coagulation factorⅧin the diagnosis of children with primary nephrotic syndrome

作　　者：马韬[1] MA Tao(Department of Clinical Laboratory,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610072,China)

机构地区：[1]成都中医药大学附属医院检验科,四川成都610072

出　　处：《国际检验医学杂志》2023年第S02期142-145,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血浆蛋白Z及凝血因子Ⅷ水平活性检测在小儿原发性肾病综合征诊断中的应用。方法选取2020年1月至2022年1月期间来该院实施小儿原发性肾病综合征救治患儿50例(25例急性期及25例恢复期)作为观察对象,将其确立为观察组;同时段选取来该院健康体检儿童50例作为对照组,并对两组观察对象抽取静脉血液,实施血浆蛋白Z(酶联免疫吸附法)及凝血因子Ⅷ水平活性(磁珠法)检测。随即比对两组观察对象血浆蛋白Z水平指数及凝血因子Ⅷ水平活性。结果通过观察结果可知,观察组血浆蛋白Z指数(0.48±0.37)显著低于对照组(1.59±0.26),凝血因子Ⅷ指数(149.58±23.18)则显著高于对照组(120.65±14.37),差异有统计学意义(P<0.05);通过数据结果可知,恢复期血浆蛋白Z(1.08±0.21)显著高于急性期(0.31±0.10),而恢复期凝血因子Ⅷ水平(135.65±14.16)显著低于急性期(159.58±23.08),组间差异有统计学意义(P<0.05)。结论相较于健康儿童,小儿原发性肾病综合征患儿自身血浆蛋白Z指数较低,凝血因子Ⅷ水平指数较高,且小儿原发性肾病综合征患儿急性发作期与恢复期血浆蛋白Z指数和凝血因子Ⅷ水平也有明显的差异。通过对两项指标的检测研究,可以明确判定小儿原发性肾病综合征病症发展情况,便于为后续治疗提供依据。Objective To explore the application of detection of plasma protein Z and coagulation factorⅧin the diagnosis of primary nephrotic syndrome in children.Methods Fifty childrens with primary nephrotic syndrome(25 cases in acute phase and 25 cases in convalescent phase)who were treated in Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2020 to January 2022 were selected as the observation group;At the same time,50 children who came to our hospital for physical examination were selected as the control group,and venous blood was taken from the two groups of observation subjects,and plasma protein Z(enzyme-linked immunosorbent assay)and coagulation factorⅧlevel activity(magnetic bead method)were detected.The plasma protein Z level index and coagulation factorⅧlevel activity of the two groups were then compared.Results According to the observation results,the plasma protein Z index(0.48±0.37)of the observation group was significantly lower than that of the control group(1.59±0.26),and the coagulation factorⅧindex(149.58±23.18)was significantly higher than that of the control group(120.65±14.37),and the differences were statistically significant(P<0.05);At the same time,according to the data,the plasma protein Z(1.08±0.21)in the recovery period was significantly higher than that in the acute period(0.31±0.10),while the level of coagulation factorⅧin the recovery period(135.65±14.16)was significantly lower than that in the acute period(159.58±23.08).The difference between groups was significant,and the differences were statistically significant(P<0.05).Conclusion Compared with healthy children,the plasma protein Z index of children with primary nephrotic syndrome is lower and the level index of coagulation factorⅧis higher,and the plasma protein Z index and coagulation factorⅧlevel of children with primary nephrotic syndrome are also significantly different in acute attack and recovery period.Through the detection and study of the two indicators,the development

关 键 词：血浆蛋白Z 凝血因子Ⅷ 小儿原发性肾病综合征 

分 类 号：R726.9[医药卫生—儿科]