CRRT与IHD疗法对ICU重症急性肾功能衰竭患者临床疗效比较  

Comparative Observation of Clinical Efficacy between CRRT and IHD Therapy for Severe Acute Renal Failure in ICU

作　　者：林美娟 杨淑贞 LIN Meijuan;YANG Shuzhen(The Affiliated Hospital of Putian University,Fujian Putian 351100)

机构地区：[1]莆田学院附属医院,福建莆田351100

出　　处：《深圳中西医结合杂志》2023年第18期17-20,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析比较连续性肾脏替代治疗(CRRT)疗法与间歇性血液透析(IHD)疗法对重症监护室(ICU)重症急性肾功能衰竭患者的疗效。方法:回顾性分析2021年5月至2023年5月莆田学院附属医院收治的104例ICU重症急性肾功能衰竭患者的临床资料,按治疗措施的不同分为对照组和观察组。其中行IHD疗法的50例患者纳入对照组,行CRRT疗法的54例患者纳入观察组,均持续治疗2周。比较两组患者临床疗效、肾功能指标、血流动力学参数、炎症因子水平。结果:观察组患者临床总有效率高于对照组,差异具有统计学意义(P <0.05)。治疗后,观察组患者血清血肌酐(Scr)、尿素氮(BUN)水平均低于对照组,差异具有统计学意义(P <0.05)。治疗后,观察组患者平均动脉压(MAP)、心脏指数(CI)高于对照组,心率(HR)低于对照组,差异具有统计学意义(P <0.05)。治疗后,观察组患者血清白细胞介素–6(IL–6)、C反应蛋白(CRP)、肿瘤坏死因子–α(TNF–α)水平均低于对照组,差异具有统计学意义(P <0.05)。结论:与IHD疗法相比,CRRT疗法更能够改善ICU重症急性肾功能衰竭患者的肾功能,稳定机体的血流动力学,控制炎症反应。Objective To analyze and compare the therapeutic effects of continuous renal replacement therapy(CRRT)and intermittent hemodialysis(IHD)on patients with severe acute renal failure in the intensive care unit(ICU).Methods A retrospective analysis was conducted on the clinical data of 104 ICU patients with severe acute renal failure admitted to The Affiliated Hospital of Putian University from May 2021 to May 2023.They were divided into a control group and an observation group according to different treatment measures.Among them,50 patients who received IHD therapy were included in the control group,and 54 patients who received CRRT therapy were included in the observation group,all of whom continued treatment for 2 weeks.The clinical efficacy,renal function indicators,hemodynamic parameters,and inflammatory factor levels between two groups of patients were compared.Results The clinical total efficiency of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum creatinine(Scr)and blood urea nitrogen(BUN)in the observation group were lower than those in the control group,with statistical significance(P<0.05).After treatment,the mean arterial pressure(MAP)and cardiac index(CI)of the observation group were higher than those of the control group,while the heart rate(HR)was lower than that of the control group,with statistically significant differences(P<0.05).After treatment,the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)of the observation group were all lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Compared with IHD therapy,CRRT therapy is more effective in improving renal function,stabilizing body hemodynamics,and controlling inflammatory response in ICU patients with severe acute renal failure.It has certain practical value.

关 键 词：重症急性肾功能衰竭 重症监护室 连续性肾脏替代治疗 间歇性血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]