耳穴埋豆联合黄柏液坐浴对肛周术后疼痛及5-HT、SP水平的影响  

Effects of auricular acupoint embedding beans combined with Huangbai Liquid sitz bath on pain,and expression levels of 5-hydroxytryptamine and serum substance P after perianal surgery

作　　者：张春秀 李方敏 孙蕾 夏佳佳 焦文娇 ZHANG Chunxiu;LI Fangmin;SUN Lei(Department of Anorectal,Binhu Campus,Hefei First People’s Hospital,Anhui,Hefei 230001,China)

机构地区：[1]安徽省合肥市第一人民医院滨湖院区肛肠科,230001

出　　处：《河北医药》2023年第24期3757-3760,共4页Hebei Medical Journal

基　　金：合肥市中医药研究项目(编号:合卫中医秘(2022)34号)。

摘　　要：目的探讨耳穴埋豆联合黄柏液坐浴对肛周术后疼痛程度、血清P物质(serum substance P,SP)、五羟色胺(serotonin,5-HT)水平的影响。方法选取2022年8月至2023年1月收治的120例肛周术后患者作为研究对象,按照随机分组法分为观察组(实施耳穴埋豆联合黄柏液坐浴干预)和对照组(采用黄柏液坐浴干预),每组60例。观察2组的疼痛情况[(numerical ratings scale,NRS评分),血清SP、5-HT],创面恢复情况,肛门功能,创面肉芽组织生长情况和并发症。结果术后第1天、术后第3天和术后第7天,观察组疼痛评分低于对照组(P<0.05)。治疗前,观察组创面渗液评分以及创面水肿评分与对照组比较,差异无统计学意义(P>0.05);术后第7天,观察组创面渗液评分以及创面水肿评分低于对照组,创面愈合时间低于对照组(P<0.05)。治疗前,2组患者的肛门功能比较,差异无统计学意义(P>0.05);术后第7天,观察组患者的肛管静息压低于对照组患者,最大收缩压高于对照组患者(P<0.05)。治疗前,2组患者的创面肉芽组织生长情况比较,差异无统计学意义(P>0.05);术后第7天,观察组患者的创面肉芽组织生长情况评分低于对照组患者(P<0.05)。治疗前,2组患者的血清因子水平比较,差异无统计学意义(P>0.05);术后第7天,观察组患者的SP、5-HT水平均低于对照组患者(P<0.05)。治疗后,观察组患者的并发症总发生率为1.67%,低于对照组患者的11.67%(P<0.05)。结论耳穴埋豆联合黄柏液坐浴能够减轻肛周术后疼痛程度,加快创面恢复,提升肛门功能,加速创面肉芽组织生长情况,值得临床推广。Objective To explore the effects of auricular acupoint embedding beans combined with Huangbai Liquid sitz bath on the pain degree and levels of serum substance P(SP)and 5-hydroxytryptamine(5-HT)after perianal surgery.Methods A total of 120 postoperative patients treated with perianal surgery in the hospital from August 2022 to January 2023 were selected as the study subjects.They were randomly divided into observation group(n=60,auricular acupoint embedding beans combined with Huangbai Liquid sitz bath)and control group(n=60,Huangbai Liquid sitz bath)by the random grouping method.The pain assessed by the Numerical Rating Scale(NRS),serum SP,5-HT,wound recovery,anal function,wound granulation tissue growth and complications were observed in the two groups.Results The NRS scores on the 1st,3rd and 7th day postoperatively were significantly lower in observation group than those of control group(P<0.05).Before treatment,there were no significant differences in the scores of wound exudation and edema between observation group and control group(P>0.05).On the 7th day after surgery,the scores of wound exudation and wound edema in observation group were significantly lower compared with those of control group,and the wound healing time was significantly shorter than that of control group(P<0.05).Before treatment,there was no significant difference in anal function between groups(P>0.05).The anal resting pressure of patients in observation group on the 7th day after surgery was significantly lower than that of control group,but the maximum systolic pressure was significantly higher(P<0.05).There was no significant difference in the growth of wound granulation tissue between the two groups before treatment(P>0.05).On the 7th day after surgery,the score of wound granulation tissue growth in observation group was significantly lower than that of control group(P<0.05).Before treatment,there were no significant differences in serum factor levels between the two groups(P>0.05).On the 7th day after surgery,SP and 5-HT levels wer

关 键 词：耳穴埋豆 黄柏液坐浴 肛周术后 血清P物质 五羟色胺 

分 类 号：R619[医药卫生—外科学]