仙方活命饮加减联合针刺对急性盆腔炎(湿热蕴结证)患者免疫功能和炎症状态的影响  

Effect of Modified Xianfang Huoming Decoction Combined with Acupuncture on Immune Function and Inflammatory Status in Patients with Acute Pelvic Inflammatory Disease(Dampness Heat Accumulation Syndrome)

作　　者：黄碗文 林智摸 余卓燊 张芷晴 米建平[3] Huang Wanwen;Lin Zhimo;Yu Zhuoshen;Zhang Zhiqing;Mi Jianping(Guangzhou University of Chinese Medicine,Guangdong,Guangzhou 510120,China)

机构地区：[1]广州中医药大学,广东广州510120 [2]广东省深圳市罗湖中医院,广东深圳518023 [3]广东省中医院二沙岛分院,广东广州510000

出　　处：《中国中医急症》2023年第12期2112-2115,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省中医药科研课题(2019FJZYJC106)。

摘　　要：目的观察仙方活命饮加减联合针刺治疗急性盆腔炎(湿热蕴结证)的临床疗效及其对免疫功能和炎症状态的影响。方法将120例患者随机分为对照组与观察组各60例。对照组给予抗感染治疗措施,给予左氧氟沙星注射液和奥硝唑注射液;观察组在对照组的基础上给予仙方活命饮加减内服和针刺治疗,疗程2周。比较两组腹痛、附件包块吸收、盆腔积液消失时间及住院时间;进行湿热蕴结证评分;检测治疗前后血肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、CD4+、CD8+、CD4+/CD8+水平;进行治疗前后妇科B超检查,比较包块大小及盆腔积液深度;比较两组临床疗效。结果治疗后观察组患者腹痛消失、附件包块吸收、盆腔积液消失时间及住院时间均短于对照组(P<0.05);观察组主要症状评分(腹痛、白带量多、腰骶疼痛)及湿热蕴结证低于对照组(P<0.05);观察组炎症因子(TNF-α、IL-1β、IL-6和hs-CRP)水平低于对照组(P<0.05);观察组CD4+和CD4+/CD8+高于对照组(P<0.05);CD8+低于对照组(P<0.05);观察组包块大小和盆腔积液深度小于对照组(P<0.05);观察组临床疗效总有效率为93.33%,高于对照组的78.33%(P<0.05)。结论在常规抗感染治疗的基础上,仙方活命饮加减联合针刺治疗急性盆腔炎(湿热蕴结证)能明显缓解症状,缩短病程,临床疗效显著,并具有抗炎和免疫调节作用。Objective:To evaluate the efficacy of modified Xianfang Huoming Decoction combined with acu⁃puncture in the treatment of acute pelvic inflammatory disease(dampness heat accumulation syndrome)and its impact on immune function and inflammatory status.Methods:A total of 120 patients were randomly divided into control group and observation group,with 60 patients in each group.The control group was given anti-infection treatment,including levofloxacin injection and ornidazole injection,while the observation group was treated with modified oral administration of Xianfang Huoming Decoction and acupuncture on the basis of the control group.The treatment period was 2 weeks.The terms of abdominal pain,absorption of adnexal masses,disappearance time of pelvic fluid accumulation,and hospitalization time were compared;scoring of dampness heat accumulation syn⁃drome were recorded;the blood tumor necrosis factor(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6),hy⁃persensitive C-reactive protein(hs-CRP),CD4+,CD8+and CD4+/CD8+levels were detected;the gynecological ul⁃trasound examination results,the size of the mass,the depth of pelvic fluid accumulation and the clinical efficacy were compared between the two groups.Result:After treatment,the time of disappearance of abdominal pain,ab⁃sorption of adnexal masses,disappearance of pelvic fluid accumulation,and hospitalization in the observation group were shorter than the control group(P<0.05);the main symptom scores(abdominal pain,excessive vaginal discharge,lumbosacral pain)and dampness heat accumulation syndrome in the observation group were lower than those in the control group(P<0.05);the levels of TNF-α,IL-1β,IL-6 and hs-CRP in the observation group were lower than those in the control group(P<0.05);the CD4+and CD4+/CD8+levels in the observation group were higher than those in the control group(P<0.05);CD8+was lower than that of the control group(P<0.05);the size of the tumor and the depth of pelvic fluid accumulation in the observation group were smaller than t

关 键 词：急性盆腔炎 湿热蕴结证 仙方活命饮 针刺 免疫功能 炎症因子 

分 类 号：R711.33[医药卫生—妇产科学]