DCE-MRI半定量参数联合ADC值对子宫恶性肿瘤的诊断价值  

Diagnostic value of semi-quantitative parameters of DCE-MRI combined with ADC values in uterine malignant tumors

作　　者：彭剑峰[1] 黄红梅[2] 王娟婷[1] 吴碧婉 曾燕妮 王虹壬 王梦意 PENG Jianfeng;HUANG Hongmei;WANG Juanting;WU Biwan;ZENG Yanni;WANG Hongren;WANG Mengyi(Department of Radiology,Huadu District People's Hospital,Guangzhou,Guangdong 510800,China;Department of Medicine,Huadu District People's Hospital,Guangzhou,Guangdong 510800,China)

机构地区：[1]广州市花都区人民医院放射科,广东广州510800 [2]广州市花都区人民医院内科,广东广州510800

出　　处：《影像研究与医学应用》2023年第20期19-22,共4页Journal of Imaging Research and Medical Applications

基　　金：广州市花都区医疗卫生一般科研专项项目(21-HDWS-021)。

摘　　要：目的:评估动态对比增强磁共振成像(DCE-MRI)半定量参数联合表观弥散系数(ADC)对子宫良恶性病变的鉴别诊断价值。方法:对34例共38个子宫肿瘤患者术前行MRI平扫、DCE-MRI及弥散加权成像(DWI)扫描,对病灶进行后处理获得DCE-MRI半定量参数:相对强度(RE)、最大相对增强率(MRE)、最大强度(ME)、达峰时间(TTP)、流出速率(WOR)、流入速率(WIR)、短暂增强时间(BOE)以及表观弥散系数(ADC),采用独立样本t检验比较各参数,并采用受试者工作特征(ROC)曲线计算各参数诊断子宫恶性肿瘤的最佳阈值。结果:恶性病变15个,良性病变23个,两组病变的半定量参数WOR、TTP及ADC值的差异有统计学意义(P<0.05),两组病变的半定量参数RE、ME、MRE、WIR、BOE的差异无统计学意义(P>0.05)。ROC曲线分析结果显示ADC值与TTP具有较好的诊断效能,而半定量参数(WOR、TTP)联合ADC值使诊断效能大大增加。结论:DCE-MRI半定量参数WOR、TTP及ADC值对诊断子宫恶性肿瘤具有较高的价值,半定量参数(WOR、TTP)联合ADC值诊断效能最高。Objective To evaluate the value of semi-quantitative parameters combined with apparent diffusion coefficient(ADC)of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the differential diagnosis of benign and malignant uterine lesions.Methods 34 patients with 38 uterine tumors were scanned with plain MRI,DCE-MRI and diffusion weighted imaging(DWI)before operation.After post-processing,relative enhancement(RE),maximum relative enhancement(MRE),maximum enhancement(ME),time to peak(TTP),wash out rate(WOR),wash in rate(WIR),brevity of enhancement(BOE)and ADC values were obtained.Independent sample t-test was used to compare the parameters.The optimal diagnostic threshold of uterine malignant tumor was diagnosed by receiver operating characteristic(ROC)curve.Results There were 15 malignant lesions and 23 benign lesions.There was significant difference in the values of semi-quantitative parameters(WOR,TTP)and ADC values between the two groups(P<0.05),but there was no significant difference in the values of semi-quantitative parameters(RE,ME,MRE,WIR,BOE)between the two groups(P>0.05).ROC curve analysis shows that ADC values and TTP have better diagnostic efficiency,while the combination of semi-quantitative parameters(WOR,TTP)and ADC values greatly increases the diagnostic efficiency.Conclusion The semiquantitative parameters(WOR,TTP)and ADC values of DCE-MRI have high predictive value for the diagnosis of uterine malignant tumors,and the combined diagnosis efficiency of ADC value and WOR,TTP is the highest.

关 键 词：子宫 肿瘤 动态增强磁共振成像 半定量参数 表观弥散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学]