消增强骨片联合西药治疗对膝骨关节炎患者疼痛症状、关节功能及氧化应激的影响  

Effects of Xiaozeng Qianggu Tablets Combined with Western Medicine Therapy on Pain Symptoms,Joint Function and Oxidative Stress in Patients with Knee Osteoarthritis

作　　者：王翠平[1] 梁翼[1] 余文景[1] 沙湖[1] 李敏[1] 许静 吴佳[1] Wang Cuiping;Liang Yi;Yu Wenjing;Sha Hu;Li Min;Xu Jing;Wu Jia(Department of Rheumatic Osteoarthropathy,Sichuan Province Orthopedic Hospital,Chengdu 610041,China)

机构地区：[1]四川省骨科医院风湿骨关节病科,成都610041

出　　处：《成都医学院学报》2023年第6期732-735,共4页Journal of Chengdu Medical College

基　　金：四川省干部保健科研课题(No:川干研2021-610)。

摘　　要：目的探讨消增强骨片联合西药治疗对膝骨关节炎(KOA)患者疼痛症状、关节功能及氧化应激的影响。方法选取2020年10月至2021年10月四川省骨科医院收治的KOA患者90例作为研究对象,按简单化随机分组法将其分为西医组(塞来昔布胶囊治疗)和中西组(消增强骨片+塞来昔布胶囊治疗),比较两组治疗后的临床疗效、疼痛症状[视觉模拟评分法(VAS)]、关节功能[西安大略大学和麦克马斯特大学关节炎指数(WOMAC)、最大主动关节活动度(AROM)]、氧化应激指标水平及药物不良反应。结果治疗后,中西组总有效率(95.56%)高于西医组(82.22%)(P<0.05)。治疗2、4周后,两组疼痛症状评分均呈降低趋势(P<0.05),且中西组评分均低于同期西医组(P<0.05)。治疗4周后,两组WOMAC评分降低(P<0.05),AROM升高(P<0.05),且中西组WOMAC评分及AROM与西医组差异有统计学意义(P<0.05)。治疗4周后,两组超氧化物歧化酶(SOD)和氧化型谷胱甘肽(GSH)水平升高(P<0.05),丙二醛(MDA)和一氧化氮(NO)水平降低(P<0.05),且中西组SOD、MDA、NO及GSH水平与西医组差异有统计学意义(P<0.05)。治疗结束后,两组心电图、三大常规、肝肾功能等均未出现异常;治疗过程中,两组均未出现严重不良反应;两组均无脱落病例。结论消增强骨片联合西药治疗可有效缓解KOA患者疼痛症状,减轻机体氧化应激损伤,促进关节功能恢复,疗效显著,安全可靠。Objective To explore the effects of Xiaozeng Qianggu tablets combined with Western medicine therapy on pain symptoms,joint function and oxidative stress in patients with knee osteoarthritis(KOA).Methods A total of 90 KOA patients admitted to Sichuan Province Orthopedic Hospital from October 2020 to October 2021 were selected as the study objects.They were randomly divided into either a Western medicine group(n=45,treated with celecoxib capsules,hereinafter referred to as the control group)or an integrated traditional Chinese and Western medicine group(n=45,treated with Xiaozeng Qianggu tablets and celecoxib capsules,hereinafter referred to as the experimental group)according to simplified random grouping method.The two groups were compared in terms of clinical efficacy,pain symptoms[Visual Analogue Scale(VAS)],joint function[Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),active range of motion(AROM)],levels of oxidative stress indicators,and adverse drug reactions after treatment.Results After treatment,the total effective rate in the experimental group(95.56%)was higher than that in the control group(82.22%)(P<0.05).The VAS scores after 2 weeks and 4 weeks of treatment showed significant downward trends in both groups(P<0.05),and the VAS scores in the experimental group were significantly lower than those in the control group(P<0.05).After 4 weeks of treatment,the WOMAC score in both groups significantly decreased(P<0.05)while the AROM value significantly increased(P<0.05),and there were significant differences in WOMAC score and AROM value between the two groups(P<0.05).After 4 weeks of treatment,the levels of superoxide dismutase(SOD)and glutathione(GSH)in both groups significantly increased(P<0.05)while the levels of malondialdehyde(MDA)and nitric oxide(NO)significantly decreased(P<0.05),and there were significant differences in the levels of SOD,MDA,NO and GSH between the two groups(P<0.05).After treatment,there were no abnormalities in electrocardiogram,three routine tests and liver-k

关 键 词：消增强骨片 塞来昔布胶囊 膝骨关节炎 疼痛 关节功能 氧化应激 

分 类 号：R285.5[医药卫生—中药学]