某职业队列人群脉压与口腔癌发病风险的研究  

Pulse pressure and risk of oral cancer in an occupational cohort

作　　者：周奕丞 赵文柳 康哲轩 舒哲 陈朔华[6] 吴寿岭[6] 李云 陈晖 ZHOU Yi-cheng;ZHAO Wen-liu;KANG Zhe-xuan;SHU Zhe;CHEN Shuo-hua;WU Shou-ling;LI Yun;CHEN Hui(School of Dentistry,North China University of Science and Technology,Tangshan 063000,China;Department of Dentistry,North China University of Science and Technology Affiliated Hospital;School of Public Health,North China University of Science and Technology;School of Basic Medical Sciences,North China University of Science and Technology;Tianjin Medical University Cancer Institute&Hospital;Kailuan General Hospital;Department of Cardiology,Kailuan General Hospital)

机构地区：[1]华北理工大学口腔医学院,唐山063000 [2]华北理工大学附属医院口腔科 [3]华北理工大学公共卫生学院 [4]华北理工大学基础医学院 [5]天津医科大学肿瘤医院 [6]开滦总医院

出　　处：《环境卫生学杂志》2023年第12期896-900,922,共6页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：河北省自然科学基金(H2021209018)。

摘　　要：目的探讨职业队列人群脉压与口腔癌发病风险的关联。方法选择开滦队列2006年度职工健康体检的符合本研究纳入排除标准的99845名参与者作为研究对象。所有参与者按脉压四分位数分组,采用Cox比例风险回归模型计算发生口腔癌的风险比(hazard ratio,HR)及其95%可信区间(95%confidence interval,95%CI),通过脉压每个标准差(s)增量来评估关联。此外,本研究还分析了高血压对口腔癌的影响。结果经过平均15.01年随访,研究人群新发口腔癌116例,Cox比例风险回归模型显示校正混杂因素后,与第一分位组比较,第二、三、四分位组发生口腔癌HR及95%CI分别为1.88(1.02,3.46)、1.94(1.04,3.61)、2.31(1.22,4.37)。脉压每升高1个s,口腔癌的发病风险升高22%(P<0.05)。相对于正常血压组,高血压1级组、高血压2级组、高血压3级组口腔癌发生风险的HR值分别是1.72(95%CI:1.10,2.67)、1.73(95%CI:0.99,3.01)和2.75(95%CI:1.37,5.52),口腔癌风险随高血压等级升高呈上升趋势(趋势性检验P<0.01)。结论在开滦职业队列人群中脉压增大增加口腔癌发病风险。高血压是口腔癌的危险因素,高血压分级越高发生口腔癌的风险越大。Objective To investigate the association between pulse pressure and the risk of oral cancer in an occupational cohort.Methods A total of 99845 participants from an occupational health screening cohort in Kailuan,China in 2006,who met the inclusion and exclusion criteria were selected.All the participants were divided into four groups according to the quartiles of pulse pressure.A Cox proportional-hazards regression model was performed to calculate the hazard ratio(HR)of oral cancer and its 95%confidence interval(95%CI).The risk of oral cancer was assessed by each increment of standard deviation(s)in pulse pressure.In addition,the effect of hypertension on oral cancer was analyzed.Results After a mean follow-up of 15.01 years,there were 116 new cases of oral cancer in the study cohort.The Cox proportional-hazards regression analysis showed that after adjusting for confounder factors,the HR and 95%CI for the occurrence of oral cancer in the second,third,and fourth quartile groups were 1.88(1.02,3.46),1.94(1.04,3.61),and 2.31(1.22,4.37),respectively,compared with the first quartile group.The risk of oral cancer increased by 22%for every one s increase in pulse pressure(P<0.05).Compared with the normal blood pressure group,the HR values for the risk of oral cancer in the grade-1,-2,and-3 hypertension groups were 1.72(95%CI:1.10,2.67),1.73(95%CI:0.99,3.01),and 2.75(95%CI:1.37,5.52),oral cancer risk increases with the hypertension level(P for trend<0.01).Conclusion A higher pulse pressure is associated with a higher risk of oral cancer in the Kailuan occupational cohort.Hypertension is a risk factor for oral cancer,and a higher grade of hypertension is linked to a higher risk of oral cancer.

关 键 词：脉压 口腔癌 队列研究 职业人群 

分 类 号：R18[医药卫生—流行病学]