益生菌在慢性创面愈合中的研究进展  

Research progress of probiotics in chronic wound healing

作　　者：林崴仪 戈成旺 唐枭伟 蔡薇[1] 宋辉[1] 李磊[1] 沈干[2] LIN Weiyi;GE Chengwang;TANG Xiaowei;CAI Wei;SONG Hui;LI Lei;SHEN Gan(Department of Burn and Plastic Surgery,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China;Department of Burn and Plastic Surgery,Affiliated Nanjing Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学第二附属医院烧伤整形科,江苏省南京市210000 [2]南京医科大学附属南京医院烧伤整形科,江苏省南京市210000

出　　处：《组织工程与重建外科》2023年第6期602-607,共6页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：慢性创面发病率高,创面愈合困难,通常需要综合治疗。现有的研究发现,应用部分益生菌及其代谢产物可以抗感染、促进创面细胞增殖、调控炎症,从而促进慢性创面的愈合,证明了益生菌应用于慢性创面愈合拥有巨大潜力。本文主要就目前益生菌在促进慢性创面愈合中的使用方法,及其与各种组织细胞的相互作用进行综述,以期为慢性创面的综合治疗提供一个新的方向。The incidence of chronic wounds is high and wound healing is difficult,which usually requires comprehensive treatment.Existing studies have found that the application of some probiotics and their metabolites can resist infection,promote wound cell proliferation,regulate inflammation and thus promote chronic wound healing,which proves the great potential of probiotics in chronic wound healing.In this paper,the current application methods of probiotics in promoting chronic wound healing and their interactions with various tissues and cells were reviewed,providing a new direction for the comprehensive treatment of chronic wounds.

关 键 词：益生菌 慢性创面 创面愈合 感染 免疫反应 

分 类 号：R457.2[医药卫生—治疗学]