康复新联合赛肤润治疗大鼠急性放射性皮肤损伤效果观察  

Therapeutic effect of Kangfuxin combined with Saifurun on acute radiation-induced skin injury in rats

作　　者：李鲤 杨晨 于洋 Li Li;Yang Chen;Yu Yang(Department of Psychiatry and Psychology,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]北部战区总医院精神心理科,辽宁沈阳110016 [2]北部战区总医院核医学科,辽宁沈阳110016

出　　处：《护理学杂志》2023年第21期72-74,共3页Journal of Nursing Science

基　　金：军队护理创新与培育专项计划项目(2021HL058)。

摘　　要：目的观察康复新联合赛肤润治疗大鼠急性放射性皮肤损伤的疗效。方法取40只SD大鼠,用放射性核素32 P敷贴固定于大鼠背部皮肤以制备急性放射性皮肤损伤模型。建模后,将大鼠随机分为模型组、康复新组、赛肤润组、康复新联合赛肤润组(联合组),各10只。模型组用生理盐水擦拭皮损处;康复新组用康复新涂抹皮损处;赛肤润组用赛肤润喷涂皮损处;联合组先涂抹康复新液,待干后喷涂赛肤润,2次/d。各组均在8:00及16:00固定时间涂抹药液。观察创面局部变化及愈合时间。治疗第2周、4周、8周时取皮损创面组织进行苏木精-伊红染色和Masson染色。结果与模型组比较,康复新组、赛肤润组、联合组的愈合时间显著缩短(均P<0.05);联合组的愈合时间显著短于康复新组及赛肤润组(均P<0.05);组织病理学检测结果显示,联合组创面组织炎性细胞浸润、水肿程度显著低于其他组,新生毛细血管数量及胶原纤维含量显著高于其他组,胶原纤维排列更整齐,表皮结构更加完整。与模型组比较,治疗第2周、4周、8周时康复新组、赛肤润组、联合组的胶原纤维含量较高(均P<0.05);与康复新组、赛肤润组相比,联合组的胶原纤维含量较高(均P<0.05)。结论康复新联合赛肤润能够减轻放射性皮肤损伤创面早期炎症反应,促进创面血管新生与胶原纤维形成,缩短创面愈合时间,加快创面修复。Objective To observe the therapeutic effect of Kangfuxin combined with Saifurun on acute radiation-induced skin injury in rats.Methods A total of 40 SD rats were selected,then radionuclide 32 P was fixed on their back skin to prepare an acute radiation skin injury model.After 2 weeks of modeling,the rats were randomized into a model group,a Kangfuxin group,a Saifurun group,and a Kangfuxin+Saifurun group,with 10 rats in each group.In the model group,the skin lesions were wiped with normal saline,the skin lesions were smeared with Kangfuxin in the Kangfuxin group,the skin lesions were sprayed with Saifurun in the Saifurun group,and in the Kangfuxin+Saifurun group,the skin lesions were smeared with Kangfuxin first,then sprayed with Saifurun twice a day after drying.Each group received medication at 8:00 and 16:00 every day.The local changes and healing time of the wound were observed.The skin lesions were taken for H-E staining and Masson staining at the 2nd,4th and 8th week of treatment.Results When compared with the model group,the healing time of the other three groups were significantly shorter(all P<0.05),and the healing time of the Kangfuxin+Saifurun group was significantly shorter than the Kangfuxin group and the Saifurun group(both P<0.05).The pathological examination results showed that,the degree of inflammatory cell infiltration and edema in the wound tissue of the combined group were significantly lower than that of the other groups,and the number of new capillaries and collagenous fiber content were significantly higher than those of the other groups,its collagenous fibers were arranged more neatly and the epidermal structure was more complete.When compared with the model group,the collagenous fiber content in the other three groups were higher at the 2nd,4th and 8th week of treatment(all P<0.05),and the collagenous fiber content in the Kangfuxin+Saifurun group was higher than those in the Kangfuxin group and the Saifurun groups(both P<0.05).Conclusion Kangfuxin combined with Saifurun can alleviate the

关 键 词：急性放射性皮肤损伤 创面愈合 动物模型 组织病理学 赛肤润 康复新 动物实验 

分 类 号：R47[医药卫生—护理学] R965.1[医药卫生—临床医学]