磁共振灌注成像技术在脑小血管病中的应用及研究进展  

Application and research progress of MR perfusion imaging in small cerebral vascular disease

作　　者：刘丹[1] 王涛[1] 魏梅 蔡吉勇 LIU Dan;WANG Tao;WEI Mei;CAI Jiyong(Department of Radiology,Bishan Hospital Affiliated to Chongqing Medical University(Chongqing Bishan District People's Hospital),Chongqing 402760,China)

机构地区：[1]重庆医科大学附属璧山医院(重庆市璧山区人民医院)放射科,重庆402760

出　　处：《磁共振成像》2023年第12期136-140,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：重庆市科卫联合医学科研项目青年项目(编号:2022QNXM041)。

摘　　要：脑小血管病是一种由于神经血管单元功能异常引起的全脑功能紊乱性疾病,是卒中和痴呆的重要原因。慢性脑缺血与低灌注、内皮功能障碍及血脑屏障(blood-brain barrier,BBB)破坏被认为是较重要的致病机制。磁共振灌注成像技术可以提供多参数的灌注信息,观察BBB通透性和血管反应性的改变,使脑小血管病有望得到早期诊断与早期逆转,也可以为潜在保护性药物的效果评估提供技术支持。本文就三种不同的磁共振灌注成像技术在脑小血管病中的实践运用及相关研究的进展情况进行综述,以期为脑小血管病的早期诊断及预后评估等提供客观依据,为未来的脑小血管病研究提供更多的视角。Cerebral small vessel disease(CSVD),a common cause of stroke and dementia,is a dynamic whole-brain dysfunction disease caused by the abnormity of the neurovascular unit.Chronic cerebral ischemia and hypoperfusion,endothelial dysfunction and blood-brain barrier(BBB)disruption are considered to be important pathogenic mechanisms.Magnetic resonance perfusion imaging technology can provide multi-parameter about perfusion information,observe the changes of BBB permeability and vascular reactivity,so that CSVD can be diagnosed earlier,the technology can also give opportunity to early reversal,and provide technical support for the verification of potential protective drug intervention.In this article,we reviewed the application and research progress of three different magnetic resonance perfusion imaging techniques in CSVD.

关 键 词：脑小血管病 磁共振成像 磁共振灌注成像 动态磁敏感对比增强成像 动态对比增强成像 动脉自旋标记 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]