磁共振扩散张量成像在脊髓损伤疾病中的研究进展  

Research progress of diffusion tensor imaging in spinal cord injury

作　　者：戚群雅 陈楠[1,2] QI Qunya;CHEN Nan(Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Beijing Key Lab of MRI and Brain Informatics,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100053 [2]北京磁共振成像和脑信息学重点实验室,北京100053

出　　处：《磁共振成像》2023年第12期151-155,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81271556、81871339)。

摘　　要：脊髓损伤(spinal cord injury,SCI)是一种高致残率、高死亡率的疾病。常规脊髓MRI可用于评估SCI后水肿和出血等引起的宏观结构改变,但无法明确损伤后轴突、髓鞘等微观结构的变化,因此难以利用常规脊髓MRI对损伤的程度及预后进行客观判断。扩散张量成像(diffusion tensor imaging,DTI)是一种无创MRI技术,能够利用组织中水分子的扩散信息反映出SCI后微观结构的变化。通过DTI的定量指标和扩散张量纤维束成像(diffusion tensor tractography,DTT)还有助于对脊髓损伤程度和患者的预后进行判断,为临床治疗决策提供更多客观的参考信息。本文通过对DTI技术在SCI疾病中的应用进行综述,旨在了解DTI在SCI疾病的研究现状,为以后DTI在SCI的研究和发展提供参考。Spinal cord injury(SCI)is a disease with high disability and mortality rates.Conventional spinal cord MRI can be used to evaluate macrostructural changes caused by edema and hemorrhage after SCI,but it cannot clearly show the changes in microstructures such as axons and myelin after injury.Therefore,it is difficult to use conventional spinal cord MRI to objectively judge the degree and prognosis of SCI.Diffusion tensor imaging(DTI)is a non-invasive MRI technique that can reflect the changes in microstructures after SCI using the diffusion information of water molecules in tissues.The quantitative indicators and diffusion tensor tractography(DTT)can help to judge the degree of injury and the prognosis of patients,providing more objective reference information for clinical treatment decisions.This article reviews the application of DTI in SCI,aiming to understand the research status of DTI in SCI and provide reference for the research and development of DTI in SCI in the future.

关 键 词：脊髓 脊髓疾病 脊髓损伤 磁共振成像 扩散张量成像 扩散张量纤维束成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744[医药卫生—诊断学]