二氮杂萘酮结构对医用聚芳醚酮表面蛋白吸附性能的影响  

Effect of Structure of Phthalazinone on the Adsorption Properties of Surface Proteins of Medical Poly(Aryl Ether Ketone)

作　　者：柳承德 于晓波 程习彤 张守海[1] 蹇锡高 Chengde Liu;Xiaobo Yu;Xitong Cheng;Shouhai Zhang;Xigao Jian(Department of Polymer Materials,School of Chemical Engineering,Dalian University of Technology,Dalian 116024,China;Liaoning High Performance Polymer Engineering Research Center,Dalian 116024,China)

机构地区：[1]大连理工大学化工学院高分子材料系,辽宁大连116024 [2]辽宁省高性能树脂工程技术研究中心,辽宁大连116024

出　　处：《高分子材料科学与工程》2023年第10期1-8,共8页Polymer Materials Science & Engineering

基　　金：宁波市重点研发计划暨“揭榜挂帅”项目(2022Z143);国家自然科学基金资助项目(U1837205)。

摘　　要：采用溶液缩聚的方法,合成含二氮杂萘酮结构的杂萘联苯聚芳醚酮(PPEK)、含萘环结构的聚芳醚酮(Nap-PAEK)和含二氮杂萘酮与萘环结构的聚芳醚酮(Nap-PPEK55) 3种不同结构的聚芳醚酮材料。通过核磁共振氢谱、红外光谱、元素分析及X射线光电子能谱证明了所合成聚合物的分子结构和元素组成。原子力显微镜及接触角分析结果表明,3种材料的表面粗糙度及润湿性基本相同。力学性能测试显示3种材料具有与骨组织相匹配的适宜模量。采用耗散型石英晶体微天平(QCM-D)和BCA法分别测试材料动态及静态蛋白质的吸附量,相比于Nap-PAEK和Nap-PPEK55,二氮杂萘酮结构含量较多的PPEK所吸附的蛋白质量明显提高。采用MC3T3-E1成骨细胞评价3种聚芳醚酮材料的生物相容性,结果表明3种材料细胞相容性良好。By solution polycondensation,three different structures of poly(aryl ether ketone)materials including poly(phthalazinone ether ketone)(PPEK)with phthalazinone,poly(aryl ether ketone)containing naphthalene(Nap-PAEK),poly(aryl ether ketone)containing phthalazinone and naphthalene structure(Nap-PPEK55)were synthesized,their structures and elemental composition of the synthesized polymers were proved by 1H-NMR,FT-IR,elemental analysis and X-ray photoelectron spectroscopy(XPS).The results of atomic force microscope(AFM)and contact angle test show that the surface roughness and wettability of the three materials are basically the same.The mechanical properties show that the three materials have suitable modulus similar to bone.The amount of dynamic and static protein adsorption of materials were tested by dissipative quartz crystal microbalance(QCM-D)and BCA method,compared with Nap-PAEK and Nap-PPEK55,the quality of protein adsorbed by PPEK with more phthalazinone structure is significantly improved.MC3T3-E1 osteoblasts were used to evaluate the biocompatibility of three kinds of PAEK.The results show that the three materials have good cell compatibility.

关 键 词：二氮杂萘酮 聚芳醚酮 蛋白质吸附 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]