糖基化在慢性炎症性疾病中的作用研究进展  

Research progress of glycosylation in chronic inflammatory diseases

作　　者：熊敏敏 苏鸿君[1] 李伟凡 黄松音[1] XIONG Min-min;SU Hong-jun;LI Wei-fan;HUANG Song-yin(Biotherapy Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,510120,China;Department of Laboratory Medicine,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,510120,China)

机构地区：[1]中山大学孙逸仙纪念医院生物治疗技术中心,广州510120 [2]中山大学孙逸仙纪念医院检验科,广州510120

出　　处：《岭南现代临床外科》2023年第5期436-443,共8页Lingnan Modern Clinics in Surgery

基　　金：国家自然科学基金(82071860);中国博士后科学基金(2022M713618);逸仙科研启航项目(YXQH202307)。

摘　　要：糖基化是将单糖或寡糖通过共价连接添加到蛋白质或脂质的过程,需要糖基转移酶和糖苷酶的参与。糖基化在病原体感染、细胞间信号传递、细胞迁移、增殖及分化等生物学过程中扮演着关键角色。众多研究已证实糖基化在慢性炎症性疾病中发挥重要作用,如炎症性肠病、慢性肾脏疾病、自身免疫性疾病及恶性肿瘤。本文概述了糖基化及其结构多样性,重点讨论了糖基化在炎症微环境和慢性炎症性疾病中的作用,以及其作为慢性炎症性疾病的诊断和治疗靶标的潜在可行性。为基于糖基化预防、诊断和治疗慢性炎症性疾病提供理论支持和新思路。Glycosylation is the process by which monosaccharides or glycans are attached to proteins or lipids under the control of glycosyltransferases and glycosidases.Glycosylation is crucial for pathogen infection,intercellular signaling,cell migration,proliferation,and differentiation.Extensive research has demonstrated the significant role of glycosylation in chronic inflammatory diseases,such as inflammatory bowel disease,chronic kidney disease,autoimmune diseases,and cancer.This article provides an over⁃view of glycosylation and its structural diversity,focusing on the role of glycosylation in the inflammatory microenvironment and its potential feasibility as a diagnostic and therapeutic target for chronic inflamma⁃tory diseases.It provides theoretical basis and new ideas for the prevention,diagnosis,and treatment of chronic inflammatory diseases based on glycosylation.

关 键 词：糖基化 慢性炎症性疾病 炎症微环境 

分 类 号：R63[医药卫生—外科学]