饮食习惯与肥胖患儿性早熟的相关性分析  

Correlation between Dietary Habits and Precocious Puberty in Obese Children

作　　者：连学刚[1] 高兰平[1] LIAN Xuegang;GAO Lanping(Department of Pediatrics,Wuzhong People's Hospital of Suzhou,Suzhou Jiangsu 215000,China)

机构地区：[1]苏州市吴中人民医院儿科,江苏苏州215000

出　　处：《临床研究》2024年第1期190-192,共3页Clinical Research

摘　　要：目的探讨饮食习惯与肥胖患儿性早熟的相关性分析。方法选取苏州市吴中人民医院2019年3月至2022年3月期间收治的72例性早熟肥胖患儿作为观察组,另选取同期体检的健康肥胖儿童71例作为常规组。采用实时-逆转录荧光定量聚合酶链反应(RT-qPCR)检测两组外周血miR-125b水平,分析患儿饮食习惯。通过比较两组肥胖儿童的外周血miR-125b、饮食习惯,采用Logistic回归分析法分析外周血miR-125b、饮食习惯与肥胖患儿性早熟的关系。结果观察组外周血miR-125b表达水平高于常规组,差异有统计学意义(P<0.05)。观察组饮食没规律、荤多素少、高添加剂食品占比均高于常规组,差异有统计学意义(P<0.05)。观察组女性患儿、不良饮食习惯占比高于常规组,且经多因素分析显示外周血miR-125b表达水平、女性、不良饮食习惯是肥胖患儿性早熟的独立危险因素,差异有统计学意义(P<0.05)。结论肥胖患儿性早熟外周血miR-125b表达水平高于健康肥胖儿童,不良饮食习惯高于健康肥胖儿童,外周血miR-125b表达水平偏高、不良饮食习惯偏低均为肥胖患儿性早熟的影响因素。Objective To explore the correlation between eating habits and precocious puberty in obese children.Methods A total of 72 obese children with precocious puberty admitted to Wuzhong People's Hospital of Suzhou City from March 2019 to March 2022 were selected as the observation group,and 71 healthy obese children who underwent physical examination during the same period were selected as the routine group.Real-time reverse transcription fluorescence quantitative polymerase chain reaction(RT-qPCR)was used to detect the level of miR-125b in peripheral blood of the two groups,and the dietary habits of the children were analyzed.By comparing the peripheral blood miR-125b and dietary habits of the two groups of obese children,Logistic regression analysis was used to analyze the relationship between peripheral blood miR-125b and dietary habits and precocious puberty in obese children.Results The expression level of miR-125b in peripheral blood of observation group was higher than that of conventional group,and the difference was statistically significant(P<0.05).The proportion of irregular diet,more meat and less vegetable,and high additives in the observation group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).The proportion of female children and poor eating habits in the observation group was higher than that in the conventional group,and multivariate analysis showed that the expression level of miR-125b in peripheral blood,female children and poor eating habits were independent risk factors for premature puberty in obese children,with statistical significance(P<0.05).Conclusion The expression level of miR-125b in the peripheral blood of obese children with precocious puberty is higher than that of healthy obese children,and the poor dietary habits are higher than that of healthy obese children.Both the high expression level of miR-125b in peripheral blood and the low poor dietary habits are the influencing factors of precocious puberty in obese children.

关 键 词：肥胖儿童 不良饮食习惯 微小核糖核酸-125b 实时-逆转录荧光定量聚合酶链反应 

分 类 号：R723.14[医药卫生—儿科]