基于组织及病理变化探讨筋针疗法对慢性骨骼肌损伤的效应机制  

The Mechanism of Tendon Acupuncture Therapy on Chronic Skeletal Muscle Injury Based on Histological and Pathological Changes

作　　者：邓小玲[1] 林星镇 袁娟[1] 侯新聚[1] 彭天忠[1] DENG Xiaoling;LIN Xingzhen;YUAN Juan;HOU Xinju;PENG Tianzhong(Department of Rehabilitation,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Jiangxi Province,Nanchang 330000,China)

机构地区：[1]南昌市洪都中医院康复科,江西南昌330000

出　　处：《中国中医药现代远程教育》2024年第2期131-133,共3页Chinese Medicine Modern Distance Education of China

基　　金：江西省卫生健康委课题【No.202140161】。

摘　　要：目的基于组织及病理变化探讨筋针疗法对慢性骨骼肌损伤的效应机制。方法选取健康雄性SD大鼠12只,采用随机数字表法分为对照组6只,造模成功后不处理;实验组6只,造模成功后给予筋针疗法治疗。比较2组雌激素相关受体α(ERRα)、乙酰化酶3(SIRT3)、锰超氧化物歧化酶(SOD2)蛋白表达,肌酸激酶(CK)、乳酸脱氢酶(LDH)活性。结果实验组ERRα、SIRT3、SOD2蛋白表达均高于对照组(P<0.05);实验组CK、LDH表达均低于对照组(P<0.05)。结论筋针治疗慢性骨骼肌损伤通过调控线粒体生物合成,降低氧化应激反应,有利于慢性骨骼肌的修复。Objective To explore the effect mechanism of tendon acupuncture therapy on chronic skeletal muscle injury based on tissue and pathological changes.Methods Twelve healthy male SD rats were selected and randomly divided into control group without treatment and experimental group with successful experimental modeling were given tendon acupuncture therapy,with 6 rats in each group.The expression of estrogen associated receptorα(ERRα)acetylase 3(SIRT3),manganese superoxide dismutase(SOD2)protein and the activities of creatine kinase(CK)and lactate dehydrogenase(LDH)were compared.Results The protein expressions of ERRα,SIRT3 and SOD2 in experimental group were higher than those in control group(P<0.05).The expression of CK and LDH in experimental group was lower than that in control group(P<0.05).Conclusion The treatment of chronic skeletal muscle injury by tendon acupuncture can regulate mitochondrial biosynthesis and reduce oxidative stress response,which is beneficial to the repair of chronic skeletal muscle.

关 键 词：筋伤 慢性骨骼肌损伤 病理变化 筋针 

分 类 号：R245[医药卫生—针灸推拿学]