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作 者:刘运辉[1] 王立平[1] 杨帆[1] LIU Yun-Hui;WANG Li-Ping;YANG Fan(Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Institute of Brain Cognition and Brain Diseases,Shenzhen-Hong Kong Institute of Brain Science Innovation,Key Laboratory of Brain Connectivity Analysis and Regulation,Chinese Academy of Sciences,Key Laboratory of Brain Connectivity Mapping in Guangdong Province,Shenzhen 518055,China)
机构地区:[1]中国科学院深圳先进技术研究院,脑认知与脑疾病研究所,深港脑科学创新研究院,中国科学院脑联结解析与调控重点实验室,广东省脑连接图谱重点实验室,深圳518055
出 处:《生理科学进展》2023年第6期468-475,共8页Progress in Physiological Sciences
基 金:国家自然科学基金(32271073,82072489);深圳市基础研究专项自然科学基金(JCYJ20220818101600001)资助课题。
摘 要:骨重塑是维持骨稳态(bone homeostasis)的重要过程,人们通常认为骨重塑主要接受内分泌激素调节。近年来,越来越多的证据表明,中枢神经系统通过传出神经直接参与骨稳态调节。虽然,大脑和骨骼组织之间已被证实存在明确的神经连接,但这些神经联系在大脑调节骨稳态中的作用还不十分清楚。本文将关注骨与脑之间的神经联系,分别从中枢神经系统和神经环路(neural circuit)、自主神经系统以及感觉神经系统对骨稳态的调控等方面介绍大脑调控骨代谢(bone metabolism)领域的最新进展。Bone remodeling is an important process for maintaining bone homeostasis,and it is commonly believed that bone remodeling is mainly regulated by endocrine hormones.In recent years,there has been increasing evidence suggesting that the central nervous system is directly involved in regulating bone homeostasis through efferent nerves.Although it has been demonstrated that there are clear neural connections between the brain and skeletal tissues,the role of these neural connections in the brain's regulation of bone homeostasis is not well understood.In this paper,we will present recent advances in the field of brain regulation of bone metabolism,focusing on the neural connections between bone and brain,the regulation of bone homeostasis by the central nervous system and neural circuit,the regulation of bone homeostasis by the autonomic nervous system and sensory nervous system,respectively.
关 键 词:神经调控 骨代谢 骨稳态 神经环路 中枢神经系统 自主神经系统 感觉神经系统
分 类 号:R336[医药卫生—人体生理学] R338[医药卫生—基础医学]
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