CTLA4Ig基因转染猪皮敷料对患儿Ⅱ度烧伤炎症反应的影响  

Effects of CTLA4Ig Gene Modified Porcine Skin Dressings on Inflammatory Reactions of Children with Second-Degree Burn

作　　者：王隽琦 王倩 赵宇辉 WANG Junqi;WANG Qian;ZHAO Yuhui(Clinical Medical School,North China University of Science and Technology,Hebei Tangshan 063000,China;DepartmentⅠof Burns and Plastics Surgery,Tangshan Gongren Hospital,Hebei Tangshan 063210,China)

机构地区：[1]华北理工大学临床医学院,河北唐山063000 [2]唐山市工人医院烧伤整形一科,河北唐山063210

出　　处：《中国医药导刊》2023年第9期942-945,共4页Chinese Journal of Medicinal Guide

基　　金：河北省医学科学研究项目(项目编号:20210758,项目名称:基因转染猪皮在面部烧伤创面中的临床应用)。

摘　　要：目的:观察人细胞毒T淋巴细胞相关抗原4免疫球蛋白(cytotoxic T lymphocyte associated antigen 4 immunoglobulin,CTLA4Ig)基因转染猪皮敷料在患儿Ⅱ度烧伤治疗中对炎症反应的影响。方法:抽取我院基因转染猪皮治疗急性烧伤的患儿40例作为观察组,银离子敷料治疗烧伤的患儿40例作为对照组。对比两组烧伤患儿的住院时长、发热天数,以及治疗前后的白细胞计数(WBC)、中性粒细胞百分比(NEUT%)、C-反应蛋白(CRP)、血清降钙素原(PCT)4种炎症指标的表达水平。结果:基因转染猪皮观察组患儿住院时间为(15.23±5.58)d,短于对照组的(18.85±11.47)d。观察组患儿发热天数为(3.60±2.35)d,少于对照组(P<0.05)。观察组患儿治疗后的WBC、CRP、PCT水平均低于对照组,且降低幅度均高于对照组(P<0.05)。结论:CTLA4Ig基因转染猪皮敷料治疗小儿Ⅱ度烧伤创面具有缩短发热时间、降低炎症反应的优点。Objective:To observe the effects of cytotoxic T lymphocyte associated antigen 4 immunoglobulin(CTLA4Ig)gene modified porcine skin dressings on inflammatory reactions of children with second-degree burn.Methods:40 cases of children with second-degree burn treated with CTLA4Ig gene modified porcine skin dressings were selected as the observation group,and 40 cases of children with second-degree burn treated with Ag+dressings were selected as the control group.The length of hospital stay,fever duration time,and the levels of inflammatory indicators(WBC,NEUT%,CRP,PCT)of the two groups of patients were compared before and after treatment.Results:The length of hospital stay of the observation group was(15.23±5.58)d,which was shorter than that of the control group(18.85±11.47).The fever duration time of patients in the observation group was(3.60±2.35)d,which was lower than that of the control group(P<0.05).After treatment,the levels of WBC,CRP and PCT of patients in the observation group were lower than those of the control group(P<0.05),and the decrease range of the WBC,CRP and PCT levels of the patients in the observation group were higher than those of the control group(P<0.05).Conclusion:The CTLA4Ig gene modified porcine skin dressings can shorten febrile time and reduce inflammatory reactions in the treatment of children with second-degree burn wounds.

关 键 词：Ⅱ度烧伤 CTLA4Ig基因转染猪皮 炎症反应 炎症指标 C-反应蛋白 

分 类 号：R392.11[医药卫生—免疫学] R622.1[医药卫生—基础医学]