非洛地平缓释片联合氢氯噻嗪治疗对高血压患者血压水平的影响分析  

Analysis of the effect of felodipine sustained-release tablets combined with hydrochlorothiazide on blood pressure levels of patients with hypertension

作　　者：杜阿胖 洪新宝 DU A-pang;HONG Xin-bao(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学附属第二医院,362000

出　　处：《中国现代药物应用》2023年第23期10-14,共5页Chinese Journal of Modern Drug Application

摘　　要：目的分析非洛地平缓释片联合氢氯噻嗪治疗对高血压患者血压水平的影响。方法100例高血压患者,根据治疗方法不同分为对照组与观察组,各50例。对照组服用非洛地平缓释片治疗,观察组在对照组治疗基础上加用氢氯噻嗪治疗。比较两组患者治疗前后的血压水平(24 h平均收缩压、24 h平均舒张压)、生活质量以及三餐后血压下降幅度、餐后低血压(PPH)发生情况。结果治疗8周后,两组患者24 h平均收缩压、24 h平均舒张压均低于治疗前,且观察组患者24 h平均收缩压(134.15±10.22)mm Hg(1 mm Hg=0.133 kPa)、24 h平均舒张压(83.49±8.59)mm Hg均低于对照组的(146.69±12.36)、(87.69±9.66)mm Hg,差异具有统计学意义(P<0.05)。治疗8周后,两组患者早餐、午餐、晚餐后血压下降幅度均小于治疗前,且观察组患者早餐后血压下降幅度(21.19±4.15)mm Hg、午餐后血压下降幅度(25.36±5.06)mm Hg、晚餐后血压下降幅度(24.32±5.03)mm Hg均低于对照组的(25.36±5.16)、(27.89±5.29)、(27.39±6.95)mm Hg,差异具有统计学意义(P<0.05)。治疗8周后,观察患者组早餐后PPH发生率30.00%、新增发病率4.00%均低于对照组的60.00%、16.00%,差异具有统计学意义(P<0.05);两组患者午餐、晚餐后PPH发生率以及新增发病率比较,差异均无统计学意义(P>0.05)。治疗8周后,两组患者躯体评分、认知评分、情绪评分、角色评分、社会功能评分均高于治疗前,且观察组患者躯体评分(81.11±8.57)分、认知评分(86.95±8.45)分、情绪评分(85.69±9.44)分、角色评分(81.48±7.28)分、社会功能评分(78.29±5.44)分高于对照组的(70.22±9.52)、(75.65±8.52)、(75.98±8.56)、(71.42±7.48)、(70.18±5.56)分,差异具有统计学意义(P<0.05)。结论针对高血压患者,应用非洛地平联合氢氯噻嗪治疗更能有效控制患者的血压水平,且不会明显增加患者临床治疗期间PPH发生率,帮助患者获得较高的生活质量,具有理�Objective To analyze the effect of felodipine sustained-release tablets combined with hydrochlorothiazide on blood pressure levels of patients with hypertension.Methods A total of 100 patients with hypertension were divided into a control group and an observation group according to different treatment methods,with50 cases in each group.The control group was treated with felodipine sustained-release tablets,and the observation group was treated with hydrochlorothiazide on the basis of the control group.Both groups were compared in terms of blood pressure(mean 24-h systolic blood pressure,mean 24-h diastolic blood pressure),quality of life,postprandial blood pressure reduction,and the occurrence of postprandial hypotension(PPH)before and after treatment.Results After 8 weeks of treatment,the mean 24-h systolic blood pressure and mean 24-h diastolic blood pressure in both groups were lower than those before treatment in this group;the mean 24-h systolic blood pressure of(134.15±10.22)mm Hg(1 mm Hg=0.133 kPa)and mean 24-h diastolic blood pressure of(83.49±8.59)mm Hg in the observation group were lower than those of(146.69±12.36)and(87.69±9.66)mm Hg in the control group;the differences were statistically significant(P<0.05).After 8 weeks of treatment,the blood pressure in both groups decreased less after breakfast,lunch and dinner than that before treatment in this group;in the observation group,the blood pressure decreased by(21.19±4.15)mm Hg after breakfast,(25.36±5.06)mm Hg after lunch,and(24.32±5.03)mm Hg after dinner,which were lower than those of(25.36±5.16),(27.89±5.29),and(27.39±6.95)mm Hg in the control group;the differences were statistically significant(P<0.05).After 8 weeks of treatment,the incidence of PPH after breakfast in the observation group was 30.00%and the incidence of new PPH was 4.00%,which were lower than those of 60.00%and 16.00%in the control group,and the differences were statistically significant(P<0.05),there was no statistically significant difference in the incidence of PPH aft

关 键 词：非洛地平缓释片 氢氯噻嗪 高血压 血压 

分 类 号：R544.1[医药卫生—心血管疾病]