风湿免疫病血液系统损害的临床表现及治疗方法探讨  

Clinical manifestations and treatment methods of blood system damage in rheumatic immune disease

作　　者：郭静[1] 刘爱英[1] GUO Jing;LIU Ai-ying(Baotou Central Hospital,Baotou 014040,China)

机构地区：[1]包头市中心医院,014040

出　　处：《中国现代药物应用》2023年第23期34-38,共5页Chinese Journal of Modern Drug Application

摘　　要：目的分析风湿免疫病血液系统损害的临床表现及治疗方法。方法80例系统性红斑狼疮患者,根据数字法随机分为对照组和观察组,各40例。对照组予以激素+吗替麦考酚酯治疗,观察组患者予以激素+环孢素治疗。比较两组患者治疗效果、血液系统损害情况、不良反应发生情况以及治疗前后的血液指标(白细胞计数、血小板计数、血红蛋白)水平、系统性红斑狼疮疾病活动度评分(SLEDAI)。结果观察组治疗总有效率95.00%高于对照组的80.00%,差异具有统计学意义(P<0.05)。治疗后,观察组患者血液系统损害发生率5.00%低于对照组的20.00%,差异具有统计学意义(P<0.05)。治疗后,观察组白细胞计数(7.69±1.02)×10^(9)/L、血小板计数(113.42±13.29)×10^(9)/L、血红蛋白(113.26±15.29)g/L均高于对照组的(6.62±0.57)×10^(9)/L、(93.63±10.39)×10^(9)/L、(100.63±8.49)g/L,差异均具有统计学意义(P<0.05)。治疗后,观察组患者SLEDAI评分(6.02±0.39)分低于对照组(6.87±0.23)分,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论风湿免疫疾病的血液系统损害表现比较多样化,但集中表现为血小板减少、全血细胞减少、贫血,在治疗中,需要重视血液系统损害情况发生。采取激素+环孢素治疗的效果较好,可以有效改善患者病症,减轻疾病的严重程度,而且不良反应少,安全性高,建议临床推广。Objective To analyze the clinical manifestations and treatment methods of blood system damage in rheumatic immune disease.Methods A total of 80 patients with systemic lupus erythematosus were randomly divided into a control group and an observation group according to random numerical table,with 40 cases in each group.The control group was treated with hormone+mycophenolate mofetil,and the observation group was treated with hormone+cyclosporine.Both groups were compared in terms of therapeutic effect,blood system damage,occurrence of adverse reactions,blood indexes(white blood cell count,platelet count,hemoglobin)and systemic lupus erythematosus disease activity index(SLEDAI)score before and after treatment.Results The total effective rate of 95.00%in the observation group was higher than that of 80.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of blood system damage in the observation group was 5.00%,which was lower than that of 20.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had white blood cell count of(7.69±1.02)×10^(9)/L,platelet count of(113.42±13.29)×10^(9)/L,and hemoglobin of(113.26±15.29)g/L,which were higher than those of(6.62±0.57)×10^(9)/L,(93.63±10.39)×10^(9)/L,and(100.63±8.49)g/L in the control group,and the differences were statistically significant(P<0.05).After treatment,SLEDAI score of(6.02±0.39)points in the observation group was lower than that of(6.87±0.23)points in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The manifestations of blood system damage in rheumatic immune diseases are more and more diversified,but the concentrated manifestations are thrombocytopenia,pancytopenia and anemia.Attention should be paid to the occurrence of blood system damage during the treatment.Its treatment with

关 键 词：风湿免疫病 血液系统损害 临床表现 治疗方法 疗效 

分 类 号：R593.2[医药卫生—内科学]