替硝唑超声震荡洗涤联合阿莫西林在牙周牙髓联合病变根管治疗中的应用效果研究  

Study on application effect of tinidazole ultrasonic wave washing combined with amoxicillin in root canal treatment of periodontal-endodontic combined lesions

作　　者：张鹏 ZHANG Peng(Department of Stomatology,Yingkou Stomatological Hospital,Yingkou 115000,China)

机构地区：[1]营口市口腔医院口腔科,115000

出　　处：《中国现代药物应用》2023年第23期140-142,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究替硝唑超声震荡洗涤联合阿莫西林在牙周牙髓联合病变根管治疗中的应用价值。方法84例接受根管治疗的牙周牙髓联合病变患者,以随机数字表法分为对照组和观察组,各42例。对照组采用替硝唑超声震荡洗涤联合氢氧化钙糊剂治疗,观察组采用替硝唑超声震荡洗涤联合阿莫西林治疗。比较两组治疗前后牙周状态[菌斑指数(PLI)、牙周探诊深度(PD)]和龈沟液炎症因子[白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)]水平。结果治疗前,两组PLI、PD比较差异无统计学意义(P>0.05);治疗后,观察组PLI(1.19±0.30)分、PD(4.68±0.53)mm均低于对照组的(1.38±0.41)分、(5.01±0.62)mm,差异具有统计学意义(P<0.05)。治疗前,两组龈沟液IL-10、TGF-β水平比较差异无统计学意义(P>0.05);治疗后,观察组龈沟液IL-10(19.72±3.04)ng/ml、TGF-β(71.35±9.80)μg/ml均高于对照组的(17.87±2.92)ng/ml、(63.64±10.78)μg/ml,差异具有统计学意义(P<0.05)。结论在牙周牙髓联合病变根管治疗中应用替硝唑超声震荡洗涤联合阿莫西林治疗,效果显著。Objective To investigate the application value of tinidazole ultrasonic wave washing combined with amoxicillin in root canal treatment of periodontal-endodontic combined lesions.Methods A total of 84 patients with periodontal-endodontic combined lesions who received root canal treatment were divided into a control group and an observation group according to the random numerical table,with 42 cases in each group.The control group was treated with tinidazole ultrasonic wave washing and calcium hydroxide paste,and the observation group was treated with tinidazole ultrasonic wave washing and amoxicillin.The periodontal status[plaque index(PLI),probing depth(PD)]and the levels of gingival fluid inflammatory biomarkers[interleukin-10(IL-10),transforming growth factor-β(TGF-β)]before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in PLI and PD between the two groups(P>0.05).After treatment,PLI of(1.19±0.30)points and PD of(4.68±0.53)mm in the observation group were lower than those of(1.38±0.41)points and(5.01±0.62)mm in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in gingival crevicular fluid IL-10 and TGF-βlevels between the two groups(P>0.05).After treatment,gingival crevicular fluid IL-10 of(19.72±3.04)ng/ml and TGF-βof(71.35±9.80)μg/ml in the observation group were higher than those of(17.87±2.92)ng/ml and(63.64±10.78)μg/ml in the control group,and the differences were statistically significant(P<0.05).Conclusion Tinidazole ultrasonic wave washing combined with amoxicillin has significant effect in root canal treatment of periodontal-endodontic combined lesions.

关 键 词：牙周牙髓联合病变 阿莫西林 替硝唑超声震荡洗涤 根管治疗 

分 类 号：R781.4[医药卫生—口腔医学]