Investigation on the Material Basis of Sijicao Granules in Treating Eczema Based on Network Pharmacology  

作　　者：Yitong SHEN Bo TU Yaru YANG Li JIANG Minghui HE Yan LIN 

机构地区：[1]School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 550025,China [2]University Engineering Research Center for the Prevention and Treatment of Chronic Diseases by Authentic Medicinal Materials in Guizhou Province,Guiyang 550025,China

出　　处：《Medicinal Plant》2023年第6期1-5,10,共6页药用植物：英文版

基　　金：Supported by Science and Technology Planning Project of Guizhou Province[QKHJC-ZK(2022)362];Science and Technology Achievements Transfer and Transformation Project of Guizhou Provincial Department of Education[(2022)064];Higher Education Institution Engineering Research Center of Guizhou Provincial Department of Education[(2023)035,No.(2023)zk01];National Undergraduate Innovation Training Project(202210660131,202310660082).

摘　　要：[Objectives]To explore the pharmacodynamic material basis of Sijicao granules for the treatment of eczema through chemical composition-network pharmacology.[Methods]First of all,the chemical constituents of Polygonum capitatum and Plantago asiatica from Sijicao granules were collected,and the relevant target information of the constituents was collected by TCMSP,PubChem,DisGeNET,GeneCards and STRING databases.Furthermore,Cytoscape 3.8.2 software was used to construct the chemical compounds-target network map of Sijicao granules.Finally,STRING database was used for PPI protein network analysis,GO functional enrichment analysis and KEGG pathway enrichment analysis of core targets,and molecular docking between core constituents and protein targets was also performed.[Results]30 constituents,including quercetin,kaempferol,luteolin,ellagic acid and gallic acid,were discovered to be the key effective compounds of Sijicao granules in the treatment of eczema.And its core action protein targets were PTGS2,NOS2,AKT1,TP53,IL6,HMOX1.What s more,through GO functional enrichment analysis of biological process(BP),cell component(CC),molecular function(MF)analysis and KEGG pathway enrichment analysis,the main pathways of action of Sijicao granules for the treatment of eczema including IL-17 signaling pathway,T cell receptor signaling pathway,cancer signaling pathway,TNF signaling pathway and Relaxin signaling pathway.In addition,molecular docking results displayed that the primary active constituents quercetin,kaempferol and luteolin were well combined with the core protein targets AKT1 and IL6.[Conclusions]Sijicao granules could play an important role for the treatment of eczema through multi-component,multi-target,multi-pathway and their interaction.

关 键 词：Sijicao granules Network pharmacology ECZEMA Polygonum capitatum Plantago asiatica L. Molecular docking 

分 类 号：R285[医药卫生—中药学]