急性肾损伤诊断的早期标志物的研究进展  

Research advances in early markers for the diagnosis of acute kidney injury

作　　者：韩云彪 赵奕雯 徐丽斌 HAN Yunbiao;ZHAO Yiwen;XU Libin(Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot010010,China;Department of Nephrology,Inner Mongolia Autonomous Region People’s Hospital,Inner Mongolia Autonomous Region,Hohhot010010,China)

机构地区：[1]内蒙古医科大学内蒙古临床医学院,内蒙古呼和浩特010010 [2]内蒙古自治区人民医院肾脏内科,内蒙古呼和浩特010010

出　　处：《中国医药导报》2023年第33期56-59,共4页China Medical Herald

基　　金：内蒙古自治区自然科学基金项目(2018LH08001)。

摘　　要：急性肾损伤(AKI)是肾内科急危重症,虽然绝大多数医师已经提高了对AKI的认识,但目前仍有较高的漏诊率及死亡率,部分患者可慢性化改变,以肌酐及尿量作为主要诊断指标单一且具有滞后性,缺乏肾小管损伤的特异性,且易受多种因素干扰,难以对AKI早期评估,但随着一些早期标志物被发现,使AKI的早期诊治成为可能。本文对部分新型诊断标志物进行部分文献总结,描述了不同标志物在AKI中可能的病理生理过程,阐述部分标志物预测AKI的可行性,同时提出AKI治疗的部分位点,为未来AKI的诊治提供方向。Acute kidney injury(AKI)is an acute and critical illness in the department of nephrology.Although most physicians have improved their understanding of AKI,there is still a high missed diagnosis rate and mortality rate.Some patients may experience chronic changes.Creatinine and urine volume is the main diagnostic indicator,which is single and hysteresis,lacks the specificity of renal tubular injury,and is easily disturbed by many factors.It is difficult to evaluate AKI early,but with the discovery of some early markers,the early diagnosis and treatment of AKI is possible.This paper summarizes some of the new diagnostic markers,describes the possible pathophysiological processes of different markers in AKI,expounds the feasibility of predicting AKI with some markers,and proposes some checking points for AKI treatment,which will provide guidance for the diagnosis and treatment of AKI in the future.

关 键 词：急性肾损伤 早期标志物 诊断 肾脏疾病 预后 

分 类 号：R692[医药卫生—泌尿科学]