肠道菌群抗病毒机制研究进展  

Research Progress in Antiviral Mechanism of Intestinal Microflora

作　　者：宫浩阳 吴佳鑫 杨晓钰 解伟纯 王雪莹 李佳璇[1,2] 姜艳平 崔文[1,2] 李一经 唐丽杰[1,2] GONG Haoyang;WU Jiaxin;YANG Xiaoyu;XIE Weichun;WANG Xueying;LI Jiaxuan;JIANG Yanping;CUI Wen;LI Yijing;TANG Lijie(College of Veterinary Medicines,Northeast Agricultural University,Harbin 150030,China;Northeast Scientific Inspection Observation Station,Key Laboratory of Animal Pathogen Biology of Ministry of Agriculture,Harbin 150030,China)

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030 [2]农业部动物疫病病原生物学重点实验室东北科学观测实验站,哈尔滨150030

出　　处：《畜牧兽医学报》2023年第12期4910-4919,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金联合基金项目(U22A20527)。

摘　　要：近年来,由于对肠道中菌群的研究不断深化,同时对肠道菌群和机体健康的关系也有了更加清晰的认识,发现肠道菌群对病毒的感染有着双重调节的作用。肠道菌群可以通过保护肠黏膜屏障以及直接与病毒结合进而中和病毒或者阻止病毒对细胞黏附的直接作用抑制病毒感染,或通过对机体免疫系统建立和发育产生影响的间接方式来抑制病毒的入侵以及分泌具有抗病毒作用的代谢产物来发挥抗病毒作用;此外,益生菌在疾病治疗中的作用也越来越突出,有望从益生菌入手解决当前治疗病毒性疾病的弊端。本文着重对近年来肠道菌群抵抗病毒感染的相关机制研究进展进行综述,并对此方向相关问题及进一步的相关研究进行展望。In recent years,with the deepening research on the intestinal microbiota and a clearer understanding of its relationship with organismal health,it has been found that the intestinal microbiota plays a dual role in regulating viral infections.The intestinal microbiota can inhibit viral infection by protecting the intestinal mucosal barrier,directly neutralizing viruses or preventing their effects on cell adhesion,indirectly influencing the establishment and development of the body′s immune system,and secreting antiviral metabolites to play an antiviral role.Moreover,probiotics have played an increasingly prominent role in disease treatment,and it is expected that probiotics can overcome the disadvantages of current viral disease treatments.This paper reviews the research progress on the mechanisms of the intestinal microbiota′s resistance to viral infection in recent years and discusses related issues and future directions for research.

关 键 词：肠道菌群 抗病毒机制 黏膜屏障 免疫调节 菌群代谢物 

分 类 号：S852.4[农业科学—基础兽医学]