副鸡禽杆菌毒力因子研究进展  

Research Progress on the Virulence Factors of Avibacterium paragallinarum

作　　者：支岩 梅晨[2] 刘珍邑 乌云格日乐 王宏俊[2] 胡格[1] ZHI Yan;MEI Chen;LIU Zhenyi;WUYUN Gerile;WANG Hongjun;HU Ge(College of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206,China;Institute of Animal Husbandry and Veterinary Medicine,Beijing Municipal Academy of Agriculture and Forestry Science,Beijing 100097,China;Zhalute Banner Livestock Breeding Center,Tongliao 029100,China)

机构地区：[1]北京农学院动物科学技术学院,北京102206 [2]北京市农林科学院畜牧兽医研究所,北京100097 [3]扎鲁特旗畜牧业良种繁育中心,通辽029100

出　　处：《畜牧兽医学报》2023年第12期4934-4942,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：北京市自然科学基金(6212009);北京市科技新星计划(20220484226)。

摘　　要：副鸡禽杆菌(Avibacterium paragallinarum,Apg)是鸡传染性鼻炎的病原菌,可以引起鸡鼻腔分泌黏液性物质、打喷嚏、眶下窦肿胀、面部水肿和结膜炎等临床症状,导致病鸡生长不良,产蛋率急剧下降,从而危害养禽生产。Apg的致病性受多种因素影响,包括荚膜、脂多糖等细胞壁结构成分和菌体分泌的功能性蛋白(如血凝素和金属蛋白酶等)。本文从生物被膜及组分、细菌分泌物、铁离子获取和利用等方面对Apg毒力因子的研究进展进行归纳和综述,以期为鸡传染性鼻炎的科学防治提供理论参考。Avibacterium paragallinarum(Apg)is the pathogen of infectious coryza in chickens.It induces symptoms such as nasal cavity mucus secretion,sneezing,infraorbital sinus swelling,facial edema,and conjunctivitis.These clinical manifestations lead to stunted growth and a significant decrease in egg production,posing a threat to poultry farming.The pathogenicity of Apg is influenced by various factors,including cell wall structural components like capsule and lipopolysaccharide,as well as functional proteins secreted by the cell such as hemagglutinin and metalloproteinases.This paper provides a review of the research progress on the virulence factors of Apg,focusing on the biofilm system,secretory system,and bacterial iron capture system.The aim is to offer a theoretical reference for the scientific prevention and treatment of infectious coryza in chickens.

关 键 词：副鸡禽杆菌 毒力因子 鸡传染性鼻炎 

分 类 号：S852.612[农业科学—基础兽医学]