儿童与成人系统性红斑狼疮临床特征和治疗后随访的对比分析  

Clinical characteristics and follow⁃up after treatment of systemic lupus erythematosus in children and adults:a comparative analysis

作　　者：刘洵薇 杨玲云 赵丽萍[1] Liu Xunwei;Yang Lingyun;Zhao Liping(Department of Nephrology and Rheumatology,Wuxi Children’s Hospital,Wuxi 214000,China)

机构地区：[1]无锡市儿童医院儿肾脏风湿免疫科,江苏无锡214000

出　　处：《海军医学杂志》2023年第11期1142-1146,共5页Journal of Navy Medicine

基　　金：无锡市卫生健康委科研项目(Q202005)。

摘　　要：目的探讨儿童和成人系统性红斑狼疮(SLE)在病情和预后方面的不同特点。方法收集2015年1月至2021年12月在无锡市儿童医院和无锡市人民医院确诊的196例SLE患者,根据发病年龄将其分为儿童组67例和成人组129例,记录2组患者入组时临床和实验室资料及随访过程中的数据资料,通过统计分析,比较2组之间各项数据差异。结果儿童组SLE起病时感染发生率、肾脏受累发生率、器官受累数量、抗核小体抗体阳性率均高于成人组(P<0.05)。儿童组SLE起病时、随访1个月时、随访6个月时和随访1年时的SLE疾病活动度评分与糖皮质激素平均日剂量均高于成人组(P<0.05)。儿童组和成人组患者艾森克人格问卷结果比较,儿童组E量表得分低于成人组(P<0.05),而N量表得分高于成人组(P<0.05)。结论儿童和成人SLE的临床表现存在一定差异。儿童SLE疾病活动度高于成人,恢复也较成人更慢。儿童SLE随访过程中应当加强糖皮质激素不良反应和心理问题的监测。Objective To compare the condition and prognosis of systemic lupus erythematosus(SLE)between children and adults.Methods A total of 196 patients diagnosed as SLE in Wuxi Children’s Hospital and Wuxi People's Hospital from January 2015 to December 2021 were enrolled.They were assigned to children group(n=67)on adult group(n=129).Clinical characteristics and laboratory data of the patients at the onset of the disease and data during follow‑up were recorded and compared between the two groups.Results The incidence of infection,the rate of kidney involvement,the number of organs involved,and the positive rate of anti‑nucleosome antibody at onset in the children group were higher than those in the adult group(P<0.05).The SLE disease activity index and the average daily dose of glucocorticoid of the children group were significantly higher than those of the adult group at onset,1‑month of follow‑up,6‑month of follow‑up,and 1‑year of follow‑up(P<0.05).The results of Eysenck personality questionnaire showed that the children group had lower score of E scale and higher score of N scale than the adult group(both P<0.05).Conclusion There are certain differences in clinical manifestations between children and adults with SLE.Children have higher SLE activity and need longer recovery time than adults.It is essential to strengthen the monitoring of glucocorticoid side effects and psychological issues in children with SLE during follow‑up.

关 键 词：系统性红斑狼疮 儿童 成人 

分 类 号：R593.24[医药卫生—内科学]