甲状腺相关指标与骨质疏松症的关系:一项基于中国南方人群的研究  

Association between Thyroid⁃related Indicators and Osteoporosis:A Population⁃based Study in Southern China

作　　者：张卓 尤丽丽 吴宏适 吴木潮[1] 徐明彤[1] 王晓艺[1] ZHANG Zhuo;YOU Li-i;WU Hong-shi;WU Mu-chao;XU Ming-tong;WANG Xiao-yi(Department of Endocrinology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510120Corresponding auther)

机构地区：[1]中山大学孙逸仙纪念医院内分泌科,510120

出　　处：《岭南急诊医学杂志》2023年第6期553-556,共4页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨华南地区人群骨质疏松症与甲状腺相关指标的关系。方法:测定华南地区人群血游离三碘甲腺原氨酸(FT3)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)、促甲状腺激素(TPO)抗体和甲状腺球蛋白抗体(TgAb)、尿碘浓度(UI)和甲状腺体积。使用超声骨密度仪测量骨密度(BMD),分为骨质疏松症组和非骨质疏松症组。使用SPSS22.0软件和R统计编程语言计算优势比(OR)。骨质疏松症的风险采用多因素Logis-tic回归分析进行评估。结果:共纳入2743名受试者,其中411人(16.6%)被诊断为骨质疏松症。皮尔逊相关分析和多元回归分析结果显示TSH、TPOAb和甲状腺体积与BMD显著相关。在单因素和多因素Logistic回归分析中,甲状腺体积和TPOAb与骨质疏松症的发生风险显著相关;甲状腺体积和TPOAb水平增加是骨质疏松的危险因素,TSH水平在正常参考范围内的增加是骨质疏松的保护因素。结论:华南地区人群血清甲状腺相关指标水平的升高与骨质疏松症的发病率独立相关。TSH在正常参考范围高值对骨质疏松有保护作用。Objective:To investigate the possible association between osteoporosis and thyroid-related indicators among thesouthern Chinese community population.Methods:Free triiodothyronine(FT3),free thyroxine(FT4),TSH,TPOAb and thyroglobulin antibody(TgAb),urine iodine(UI)and thyroid volume were measured of thesouthern Chinese community population.Bone mineral density was measured using an ultrasound bone densitometer and divided into osteoporosis and non-osteoporosis groups.SPSS 22.0 software and R statistical programming language were used.The risk of osteoporosis was assessed by theunadjusted and multivariate-adjusted logistic regression analysis.Results:A total of 2743 subjectswere recruited in this study,and 411(16.6%)were diagnosed with osteoporosis.Thyrotropic-stimulat-ing hormone(TSH),thyroid peroxidase antibody(TPOAb)and thyroid volumewere significantly associated with BMD.Thyroid volume and TPOAb were associated with significantly increased odds of osteoporosis.Increased thyroid volume and TPOAb leveltended to be risk factors of osteoporosis,and increased TSH level in the normal reference range tended to be a protective factor of osteoporosis.Conclusion:Increased serum thyroid-related indicator levels are independently associated with the incidence of osteoporosis in thesouthern Chinese community population.Of the thyroid-related indica-tors,TSH withinthe normal reference range has protective effects on osteoporosis.

关 键 词：骨质疏松症 甲状腺相关指标 甲状腺体积 TSH TPOAB 

分 类 号：R580[医药卫生—内分泌]