氟吡汀和抗组胺药对小鼠福尔马林致痛的协同镇痛作用  

Flupirtine and Antihistamines Exert Synergistic Analgesic Effect in Mice Formalin Model

作　　者：陈衍铭 庄涛 CHEN Yan-ming;ZHUANG Tao(School of Pharmacy,Jiangsu Ocean University,Lianyungang 222000,China)

机构地区：[1]江苏海洋大学药学院,江苏连云港222000

出　　处：《西北民族大学学报（自然科学版）》2023年第4期62-68,共7页Journal of Northwest Minzu University(Natural Science)

基　　金：江苏省高等学校重点学科发展计划资助项目(2022JSPAPD006);江苏省高等学校自然科学研究面上项目(21KJB350002)。

摘　　要：镇痛机制复杂、涉及环节多,单药使用具有局限性,因而采用多模式镇痛是医学发展的必然结果.文章旨在评价氟吡汀(Kv7通道开放剂)和抗组胺药(异丙嗪、非索非那定)新组合对小鼠福尔马林致痛的镇痛作用.首先通过实验获得氟吡汀、异丙嗪和非索非那定的ED 50,然后选用同一效应水平的联合应用(1/8ED 50+1/8ED 50,1/4ED 50+1/4ED 50,1/2ED 50+1/2ED 50),接着通过等辐射分析法评价氟吡汀和抗组胺药在小鼠福尔马林致痛模型中的相互作用关系.氟吡汀、异丙嗪和非索非那定的ED 50分别为18.42 mg/kg、4.49 mg/kg、12.98 mg/kg.氟吡汀-异丙嗪联合用药组和氟吡汀-非索非那定联合用药组的相互作用指数γ分别为0.56、0.51,均<1.研究结果表明,氟吡汀与抗组胺药(异丙嗪、非索非那定)能产生协同镇痛作用.氟吡汀与抗组胺药的协同作用为临床多模式镇痛提供了新的选择.The complex and multifaceted analgesic mechanisms and the limitations of single drug use made the use of multimodal analgesia a natural consequence of medical developments.This study aimed to evaluate the analgesic effects of a new combination of flupirtine(Kv7 channel opener)and antihistamines(promethazine,fexofenadine)on formalin-induced pain in mice.ED50 of flupirtine,promethazine and fexofenadine were experimentally obtained,then the same effect level was chosen for the combination(1/8ED50+1/8ED50,1/4ED50+1/4ED50,1/2ED50+1/2ED50),followed by the evaluation of the interaction between flupirtine and antihistamines in formalin-induced pain model by isobolographic analysis.ED50 for flupirtine,promethazine and fexofenadine were 18.42,4.49 and 12.98 mg/kg respectively.The interaction indexγwas 0.56 and 0.51 for the flupirtin-promethazine and flupirtin-fexofenadine combination groups,respectively,both of which were<1.The study showed that flupirtin and antihistamines(promethazine and fexofenadine)could produce synergistic analgesic effects.The synergistic effect of flupirtine and antihistamines provided a new option for multimodal clinical analgesia.

关 键 词：氟吡汀 抗组胺药 协同作用 镇痛 等辐射分析 

分 类 号：R96[医药卫生—药理学]