中医药临床研究证候标准化诊断的研究思路与方法  

Research Ideas and Methods for Standardization of Traditional Chinese Medicine Syndrome Differentiation

作　　者：罗慜婧 柴倩云[1] 冯玉婷 高一城 夏如玉 王雅琪 刘建平[1] 费宇彤[1] LUO Mingjing;CHAI Qianyun;FENG Yuting;GAO Yicheng;XIA Ruyu;WANG Yaqi;LIU Jianping;FEI Yutong(Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine,Beijing,100029)

机构地区：[1]北京中医药大学循证医学中心,北京市100029

出　　处：《中医杂志》2023年第24期2505-2510,共6页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81830115)。

摘　　要：辨证论治是中医诊断疾病的特有模式,探索科学规范的证候标准化诊断方法是客观、系统地评价中医药临床疗效的重要环节,也是中医药推广发展取得国际认可的前提条件。通过回顾现有相关证候诊断标准的基本模式及存在的问题,提出构建集最小化核心症状集、人工智能体征信息采集、多模态实验室指标、多组学特异性标志物为一体的病证结合中医证候标准化诊断多维核心信息集,从多角度系统化体现证候特征。阐述该证候标准化诊断研究方法的基本模式、结构组成及建立时应采用的流程和方法。认为此证候诊断核心信息集,既考虑了疾病的特异性,又可弥补由于辨证的复杂性和主观性特点而导致的证候诊断一致性欠佳的不足,可为中医临床研究中证候的标准化诊断提供方法学依据。Syndrome differentiation and treatment is a unique mode of diagnosis in traditional Chinese medicine(TCM).The establishment of scientific and standardized syndrome diagnosis standards is an important link to evaluate the clinical efficacy of TCM objectively and systematically,and also a prerequisite for the promotion and development of TCM to obtain international recognition.This article reviewed the basic modes and existed problems of the current syndrome diagnosis criteria,and proposed to construct a multidimensional core information set integrating the mini⁃mized core symptoms,the artificial intelligence signs,the multi-modal laboratory indicators,and multi-omics specific markers,so as to present syndrome characteristics from multiple perspectives systematically.This paper also described the basic mode,constructure,as well as the process and methodology to be adopted in the establishment of the stan⁃dardized diagnostic research method.The core information set of diagnostic symptoms not only took into account the specificity of the disease,but also improved the inconsistency due to the complexity and subjectivity of the syndrome differentiation,thereby providing a methodological basis for the standardization of TCM syndrome differentiation in clinical research.

关 键 词：中医证候 标准化诊断 核心症状集 多维核心信息集 中医药临床研究 

分 类 号：R259[医药卫生—中西医结合]