运动缓解创伤后应激障碍恐惧记忆泛化及成体海马神经再生机制研究进展  

Advances in the role of adult hippocampal neurogenesis in physical exercise-mediated mitigation of fear memory generalization in post-traumatic stress disorder

作　　者：金硕 许子萱 卢山 张晓晓 孙丽娜[1,2] JIN Shuo;XU Zi-Xuan;LU Shan;ZHANG Xiao-Xiao;SUN Li-Na(College of P.E and Sports,Beijing Normal University,Beijing 100875,China;State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing 100875,China)

机构地区：[1]北京师范大学体育与运动学院,北京100875 [2]北京师范大学认知神经科学与学习国家重点实验室,北京100875

出　　处：《生命科学》2023年第11期1508-1516,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(32000835);北京师范大学认知神经科学与学习国家重点实验室开放课题(CNLZD2104)。

摘　　要：运动可通过成体海马神经再生(adult hippocampal neurogenesis,AHN)促进模式分离从而有效缓解创伤后应激障碍(post-traumatic stress disorder,PTSD)恐惧记忆泛化,即通过运动促进AHN可以减少PTSD患者的恐惧记忆对相似记忆的干扰,从而缓解PTSD患者的恐惧记忆泛化,这为运动干预有效治疗PTSD恐惧记忆泛化的可行性提供了理论支持。该文阐述了运动促进的AHN改善PTSD恐惧记忆泛化的研究进展,以期为PTSD基础研究及治疗提供新思路。Physical exercise can promote pattern separation through adult hippocampal neurogenesis(AHN)to effectively alleviate fear memory generalization in post-traumatic stress disorder(PTSD),which means that promoting AHN through physical exercise can reduce the interference of fear memory in similar memories in PTSD patients,thereby alleviating their fear memory generalization.This provides theoretical support for the feasibility of physical exercise intervention to effectively treat fear memory generalization in PTSD.This paper describes the research progress of physical exercise promoted AHN to improve fear memory generalization in PTSD,with a view to provide new ideas for basic research and treatment of PTSD.

关 键 词：运动 创伤后应激障碍 恐惧记忆泛化 成体海马神经再生 

分 类 号：R395.4[哲学宗教—心理学] R455[医药卫生—医学心理学] R749[医药卫生—基础医学]