中老年男性血尿酸与血管钙化的相关性研究  

The study on the correlation between serum uric acid and vascular calcification in middle-aged and elderly men

作　　者：刘栩晗 梁雪[1] 高政南 李欣宇[1] Liu Xuhan;Liang Xue;Gao Zhengnan;Li Xinyu(Department of Endocrinology,Dalian Central Hospital,Dalian University of Technology,Dalian 116033,China)

机构地区：[1]大连理工大学附属大连市中心医院内分泌科,大连116033

出　　处：《中国医师进修杂志》2023年第12期1076-1080,共5页Chinese Journal of Postgraduates of Medicine

基　　金：2020年大连市医学科学研究计划项目(2011007)。

摘　　要：目的研究中老年男性血尿酸(SUA)与血管钙化的相关关系。方法回顾性通过医渡云电子病历检索系统,选取2010年1月至2022年10月在大连理工大学附属大连市中心医院住院的2786例年龄≥40岁行肺CT检查的男性患者的临床资料,根据肺CT血管钙化情况分为血管钙化组(1296例)及无血管钙化组(1490例)。收集两组患者的临床资料,分析SUA与血管钙化的相关性。结果血管钙化组SUA水平高于无血管钙化组[311.50(270.25,359.00)μmol/L比284.00(251.00,318.00)μmol/L],差异有统计学意义(F=14.16,P<0.01)。血管钙化组高尿酸血症占比高于无血管钙化组[25.62%(332/1296)比11.68%(174/1490)],差异有统计学意义(χ^(2)=20.15,P<0.01)。Spearman相关性分析发现,中老年男性SUA水平与血管钙化呈正相关关系(r=0.489,P<0.01)。二元Logistic回归分析结果表明,SUA、体质量指数(BMI)、舒张压(DBP)、空腹血糖(FPG)是血管钙化的危险因素(P<0.01);调整BMI、DBP、FPG对男性血管钙化的影响后,SUA仍是血管钙化的危险因素。结论在中老年男性人群中,随着SUA升高,血管钙化增加,增高的SUA水平是血管钙化的独立危险因素。Objective To study the correlation between serum uric acid(SUA)and vascular calcification in middle-aged and elderly men.Methods Using the Yiduyun electronic medical record retrieval system,a cross-sectional study was conducted on the clinical data of 2786 male patients aged≥40 years who underwent lung CT examinations in Dalian Central Hospital,Dalian University of Technology from January 2010 to October 2022.According to the degree of pulmonary CT vascular calcification,they were divided into vascular calcification group(1296 cases)and non vascular calcification group(1490 cases).The clinical data were collected and the correlation between SUA and vascular calcification were analyzed.Results The levels os SUA in the vascular calcification group was higher than that in the non vascular calcification group:311.50(270.25,359.00)μmol/L vs.284.00(251.00,318.00)μmol/L,there was statistical difference(F=14.16,P<0.01).The constituent ratio of hyperuricemia in vascular calcification group was higher than that in non vascular calcification group:25.62%(332/1296)vs.11.68%(174/1490),there was statistical difference(χ^(2)=20.15,P<0.01).Spearman correlation analysis found a positive correlation between SUA level and vascular calcification in middle-aged and elderly men(r=0.489,P<0.01).Binary Logistic regression analysis results showed that SUA,body mass index(BMI),diastolic blood pressure(DBP),fasting plasma glucose(FPG)were positively correlated with vascular calcification(P<0.01);after adjusting the influence of BMI,DBP and FPG on male vascular calcification,SUA was still a risk factor for vascular calcification.Conclusions In the middle-aged and elderly male population,with the increase of blood uric acid,vascular calcification increase,and the elevated blood uric acid level is an independent risk factor for vascular calcification.

关 键 词：尿酸 血管钙化 中老年 男人 

分 类 号：R543[医药卫生—心血管疾病]