Genetic Architecture and Functional Implications of the CSF‑Contacting Nucleus  

作　　者：Siyuan Song Yumin Yuan Lingling Xu Jun Jiang Ying Li Yao Yan Qing Li Fang Zhou Junli Cao Licai Zhang 

机构地区：[1]Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China [2]Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou Medical University,Xuzhou 221004,China [3]NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou 221008,China [4]School of Nursing,Xuzhou Medical University,Xuzhou 221004,China

出　　处：《Neuroscience Bulletin》2023年第11期1638-1654,共17页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China,2021 Original Exploration Program recommended by experts(82150007);the Natural Science Foundation of Jiangsu Province(BK20190987);and the Chinese Postdoctoral Science Foundation(2018M642328).

摘　　要：We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were about 19,666 genes in this nucleus,of which 913 were distinct from the dorsal raphe nucleus(non-CSF contacting).The top 40 highly-expressed genes are mainly related to energy metabolism,protein synthesis,transport,secretion,and hydrolysis.The main neurotransmitter is 5-HT.The receptors of 5-HT and GABA are abundant.The channels for Cl–,Na+,K+,and Ca2+are routinely expressed.The signaling molecules associated with the CaMK,JAK,and MAPK pathways were identified accurately.In particular,the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.The relationship between the main genes of the nucleus and life activities is preliminarily verified.

关 键 词：Gene architecture Cerebrospinal fluidcontacting nucleus(CSF-contacting nucleus) Biological function 

分 类 号：R512.3[医药卫生—内科学]