Chiral amino acid recognition in water:A BINOL-based fluorescent probe  

作　　者：Meng-Xin Sun Chuan-Zhi Ni Fang-Qi Zhang Yuan-Yuan Zhu Jie Zeng Shuang-Xi Gu 

机构地区：[1]School of Chemistry and Environmental Engineering,Wuhan Institute of Technology,Wuhan 430205,China [2]Hubei Key Laboratory of Novel Reactor and Green Chemical Technology,Wuhan Institute of Technology,Wuhan 430205,China [3]Pharmaceutical Research Institute,Wuhan Institute of Technology,Wuhan 430205,China [4]Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering&Pharmacy,Wuhan Institute of Technology,Wuhan 430205,China

出　　处：《Chinese Chemical Letters》2023年第12期136-140,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(Nos.21877087,22074114);Natural Science Foundation of Hubei Province of China(Nos.2020CFB623,2021CFB556);Key Laboratory for Green Chemical Process of Ministry of Education(No.GCP20200201);Hubei Key Laboratory of Novel Reactor and Green Chemical Technology(No.40201002);Wuhan Institute of Technology Graduate Education and Teaching Reform Research Project(Nos.2022JYXM09,2021JYXM07);Wuhan Institute of Technology Graduate Innovation Fund(Nos.CX2022450,CX2022009,CX2022058)are greatly appreciated.

摘　　要：A novel BINOL-based fluorescence probe(S)-6 featuring a sodium sulfonate fragment at the 2'-position was designed and synthesized via simple synthetic procedures under mild reaction conditions.The watersoluble probe(S)-6 displays excellent enantioselective recognition toward 15 common amino acids,and it can be used for enantiomeric excess determination of amino acids.The fluorescence intensity of(S)-6 treated with amino acids reaches the maximum after standing for only 30 min at room temperature and remains stable in the following 5.5 h,which has great potential in the application of chiral fluorescence analysis due to its timeliness and outstanding fluorescent stability.

关 键 词：Chiral recognition Fluorescent probe Amino acid WATER-SOLUBLE Enantiomeric excess determination 

分 类 号：O623.736[理学—有机化学] O657.3[理学—化学]