我国病原真菌相关的公共卫生风险浅析  

Analysis of public health risks associated with pathogenic fungi in China

作　　者：龚杰 耿圆圆 张舒 刘伟[2] 吴伟伟 李若瑜[2] 张建中[1] Gong Jie;Geng Yuanyuan;Zhang Shu;Liu Wei;Wu Weiwei;Li Ruoyu;Zhang Jianzhong(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention/Peking University First Hospital-National Institute for Communicable Disease Control and Prevention Joint Laboratory of Pathogenic Fungi,Beijing 102206,China;Department of Dermatology,Peking University First Hospital/National Clinical Research Center for Skin and Immune Diseases/Research Center for Medical Mycology,Peking University/Beijing Key Laboratory of Molecular Diagnosis on Dermatoses/Peking University First Hospital-National Institute for Communicable Disease Control and Prevention Joint Laboratory of Pathogenic Fungi,Beijing 100034,China;Derpartment of Plastic and Dermatologic Surgery,the Fifth People's Hospital of Hainan Province,Haikou 570102,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心传染病预防控制所/北京大学第一医院-中国疾病预防控制中心传染病预防控制所病原真菌联合实验室,北京102206 [2]北京大学第一医院皮肤性病科/国家皮肤与免疫疾病临床医学研究中心/北京大学真菌和真菌病研究中心/皮肤病分子诊断北京市重点实验室/北京大学第一医院-中国疾病预防控制中心传染病预防控制所病原真菌联合实验室,北京100034 [3]海南省第五人民医院整形与皮肤外科,海口570102

出　　处：《中华流行病学杂志》2023年第12期1977-1983,共7页Chinese Journal of Epidemiology

基　　金：国家重点研发计划(2022YFC2504800);国家自然科学基金(81972948)。

摘　　要：目前在我国由病原真菌引起的公共卫生风险较大,已引起疾控部门的高度关注。由于真菌感染诊断相对困难,目前病原真菌的公共卫生风险往往隐藏于不明原因肺炎、脑炎、发热症候群等中,并未得到有效重视。基于公共卫生视角,重点关注的病原真菌主要涉及高致病性真菌(包括双相真菌和暗色真菌)、造成区域性聚集感染的病原真菌和耐药病原真菌。由于缺乏系统的监测数据,对病原真菌相关的疾病负担无法进行准确量化评估。为有效降低病原真菌感染对我国人群的危害,应做好国家层面的病原真菌系统性监测工作。At present,the public health risks caused by pathogenic fungi are greater in China and have attracted great attention from disease control departments.Due to the difficulty in diagnosing fungal infections,the public health risk of pathogenic fungi is currently hidden in the unexplained pneumonia/encephalitis/fever syndrome and is not effectively appreciated.From the public health perspective,the mainly focused fungal pathogens include highly pathogenic fungi(including dimorphic fungi and dematiaceous fungi),pathogenic fungi that cause regional aggregation infections,and drug-resistant pathogenic fungi.However,due to the lack of systematic monitoring data,the disease burden related to pathogenic fungi cannot be accurately quantified and evaluated.Therefore,to effectively reduce the serious harm of fungal infections to the public,systematic monitoring of pathogenic fungi should be carried out nationally.

关 键 词：病原真菌 公共卫生风险 双相真菌 暗色真菌 感染 耐药 

分 类 号：R519[医药卫生—内科学]