INTERGROWTH-21^(st)标准结合主动脉峡部血流参数评价晚发型胎儿生长的影响  

INTERGROWTH-21^(st)standard combined with aortic isthmus blood flow parameters to evaluate the impact of late onset fetal growth

作　　者：许传塍 肖雪花 杨海云 叶萍 Xu Chuancheng;Xiao Xuehua;Yang Haiyun;Ye Ping(Department of Ultrasound,Affiliated Hospital of Jiujiang University,Jiujiang 332000)

机构地区：[1]九江学院附属医院超声科,九江332000

出　　处：《中华实验外科杂志》2023年第11期2374-2377,共4页Chinese Journal of Experimental Surgery

基　　金：江西省卫生健康委科技计划(20191824)。

摘　　要：目的:探讨INTERGROWTH-21^(st)标准结合主动脉峡部血流参数评价晚发型胎儿生长受限(FGR)的意义。方法:选取九江学院附属医院2020年1月至2023年1月在进行常规产前检查并入院分娩的100例孕妇为研究的对象,根据孕产妇的分娩结局分为正常胎儿组(88例)和晚发型胎儿生长受限组(12例),所有孕产妇均行彩色多普勒超声检测胎儿主动脉峡部血流指数(IFI)及峡部收缩指数(ISI),并以超声监测相关参数,包括双顶径(BPD)、头围(HC)、股骨长(FL)、腹围(AC)等;分别以INTERGROWTH-21^(st)公式与INTERGROWTH-21^(st)公式结合主动脉峡部血流参数对胎儿体重进行预测,比较两种方式对FGR的预测准确性。计量资料以均数±标准差(±s)表示,采用t检验,计数资料以率(%)表示.采用χ^(2)检验。结果:本组100例孕妇分娩结局,88例为正常胎儿,12例为FGR。正常组胎儿体质量及新生儿Apgar评分(3.591±0.420,1.643±0.420),晚发组胎儿体质量及新生儿Apgar评分(8.260±1.500,6.760±1.812),两组间差异有统计学意义(χ^(2)=4.561,P<0.05)。正常组胎儿双顶径为(8.320±0.790)cm,头围为(29.460±5.780)cm,股骨长为(70.126±6.831)cm,腹围为(30.641±3.290)cm,晚发组胎儿双顶径[(7.122±0.218)cm],头围[(23.141±2.800)cm],股骨长[(62.430±4.780)cm],腹围[(28.414±2.780)cm]直径均值低于正常组,差异有统计学意义(χ^(2)=18.923,P<0.05)。晚发型FGR组胎儿主动脉峡部舒张期血流消失或反向发生率42.25%(5/12),高于对照组13.40%(1/12),差异有统计学意义(χ^(2)=2.110,P<0.01)。INTERGROWTH-21^(st)标准结合主动脉峡部血流参数对FGR预测的准确性为92.0%(92/100),单纯INTERGROWTH-21^(st)标准对FGR预测的准确性为81.0%(81/100),两者差异有统计学意义(χ^(2)=5.181,P<0.05)。结论:INTERGROWTH-21^(st)标准结合主动脉峡部血流参数评价FGR中的作用显著,有助于评价晚发型胎儿生长受限。Objective To explore the significance of evaluating late onset fetal growth restriction(FGR)using the INTERGROWTH-21^(st)(international Fetal and Newborn Growth Consortium for the 21^(st) Century)standard combined with aortic isthmus blood flow parameters.Methods From January 2020 to January 2023,100 pregnant women who underwent routine prenatal examinations and delivered in affiliated hospital of jiujiang university were selected as the research subjects.They were divided into a normal fetal group(88 cases)and a late onset fetal growth restriction group(12 cases)based on their delivery outcomes.All pregnant women were tested for fetal aortic isthmus flow index(IFI)and isthmus systolic index(ISI)using color Doppler ultrasound,and related parameters were monitored using ultrasound,including biparietal diameter(BPD),head circumference(HC)Femur length(FL),abdominal circumference(AC),etc;Using the INTERGROWTH-21^(st) formula and the INTERGROWTH-21^(st) formula combined with aortic isthmus blood flow parameters to predict fetal weight,and comparing the accuracy of the two methods in predicting FGR.Measurement data is represented by±s,t-test is used,and counting data is represented by rate(%),usingχ^(2) tests,with P<0.05 as the difference with statistical significance.Results The delivery outcomes of 100 pregnant women in this group were 88 normal fetal and 12 FGR.The differences between the normal group’s fetal body mass and neonatal Apgar score(3.591±0.420,1.643±0.420)and the late onset group’s fetal body mass and neonatal Apgar score(8.260±1.500,6.760±1.812)were statistically significant(χ^(2)=4.561,P<0.05).Compared with the normal group fetuses with biparietal diameter(8.320±0.790)cm,head circumference(29.460±5.780)cm,femoral length(70.126±6.831)cm,and abdominal circumference(30.641±3.290)cm,the late onset group fetuses with biparietal diameter(7.122±0.218)cm,head circumference(23.141±2.800)cm,femoral length(62.430±4.780)cm,and abdominal circumference(28.414±2.780)cm had a statistically significa

关 键 词：INTERGROWTH-21^(st)标准 主动脉峡部血流 晚发型胎儿宫内生长受限 

分 类 号：R714.5[医药卫生—妇产科学]